DNA damage in children and adolescents with cardiovascular disease risk factors
| Autor: | Mariele Kliemann, Silvia Isabel Rech Franke, Miriam Beatris Reckziegel, Juliana da Silva, Miria Suzana Burgos, Luiza Louzada Müller, Sharbel Weidner Maluf, Liziane Hermes, Jorge André Horta, Daniel Prá |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent DNA damage Physiology Disease medicine.disease_cause Risk Factors Prevalence Medicine Humans Child Multidisciplinary business.industry Anthropometry Lipids Comet assay Glucose Cardiovascular Diseases Micronucleus test Disease risk Female Comet Assay business Micronucleus Oxidative stress Biomarkers DNA Damage |
| Zdroj: | Anais da Academia Brasileira de Ciencias. 84(3) |
| ISSN: | 1678-2690 |
| Popis: | The risk of developing cardiovascular disease (CVD) is related to lifestyle (e.g. diet, physical activity and smoking) as well as to genetic factors. This study aimed at evaluating the association between CVD risk factors and DNA damage levels in children and adolescents. Anthropometry, diet and serum CVD risk factors were evaluated by standard procedures. DNA damage levels were accessed by the comet assay (Single cell gel electrophoresis; SCGE) and cytokinesis-blocked micronucleus (CBMN) assays in leukocytes. A total of 34 children and adolescents selected from a population sample were divided into three groups according to their level of CVD risk. Moderate and high CVD risk subjects showed significantly higher body fat and serum CVD risk markers than low risk subjects (P |
| Databáze: | OpenAIRE |
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