Evaluation of the Possibility of Correction of Doxorubicin-Induced Chronic Heart Failure in the Experiment with 3-Hydroxypyridine Acetylcysteinate and 3-Hydroxypyridine Succinate
| Autor: | M. N. Zamotaeva, V. V. Konorev, Y V Kuznetsov, V. I. Inchina, N D Kuzmichev |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cardiotonic Agents Pyridines Pharmacology General Biochemistry Genetics and Molecular Biology Antioxidants 03 medical and health sciences 0302 clinical medicine Malondialdehyde medicine Animals Creatine Kinase MB Form Urea Doxorubicin Heart Failure Antibiotics Antineoplastic business.industry Alanine Transaminase Heart General Medicine medicine.disease Catalase Acetylcysteine Rats 030104 developmental biology Heart failure Picolines Potassium business 030217 neurology & neurosurgery Injections Intraperitoneal medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 165(3) |
| ISSN: | 1573-8221 |
| Popis: | The possibility of correction of morphological changes in the myocardium and biochemical parameters of the blood with 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg was studied in the model of doxorubicin-induced chronic heart failure in rats. It was found that 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg produced less pronounced cardio-protective effect in experimental chronic heart failure than 3-hydroxypyridine succinate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink