Gastric emptying in healthy children using the Spirulina breath test: The impact of gender, body size, and pubertal development
| Autor: | Katja Kovacic, Louis Pawela, Manu R. Sood, Melodee Nugent Liegl, Pippa Simpson, Liyun Zhang |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Adolescent Physiology Quadratic model Body size Cohort Studies Excretion 03 medical and health sciences Pubertal stage 0302 clinical medicine Reference Values 030225 pediatrics Appetite Depressants Spirulina medicine Body Size Humans Child Breath test Body surface area Sex Characteristics Gastric emptying medicine.diagnostic_test Endocrine and Autonomic Systems business.industry Puberty Gastroenterology Carbon Dioxide Healthy Volunteers Breath Tests Gastric Emptying Cohort Female 030211 gastroenterology & hepatology business |
| Zdroj: | Neurogastroenterology & Motility. 33 |
| ISSN: | 1365-2982 1350-1925 |
| DOI: | 10.1111/nmo.14063 |
| Popis: | BACKGROUND There are no pediatric norms for gastric emptying (GE) measured by nuclear scintigraphy. The 13 C-labeled, stable isotope GE breath test (GEBT) is a non-radioactive alternative. We aimed to determine normative GEBT ranges in a cohort of healthy children and examine the influence of age, gender, puberty, and body surface area (BSA). METHODS Healthy children ages 8-18 years completed the [13 C]-Spirulina platensis GEBT after an overnight fast. Breath samples were collected at baseline, every 15 min × 1 h, then every 30 min for 4 h total. The 13 CO2 excretion rate was determined by the change in 13 CO2 /12 CO2 over time in each breath sample, expressed as kPCD (Percent 13 C Dose excreted/min). A mixed model with random time was used for multivariable analysis and outcome fit into a quadratic model. KEY RESULTS The 100 subjects completed the test meal within allotted time. Median (IQR) age was 13.5 (11.3-15.5) years; 51% were female. Females had lower 13 CO2 excretion rates (slower GE) than males across time (p |
| Databáze: | OpenAIRE |
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