Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer
| Autor: | Yang Yang, Hu Tc, Huang X, Cui Zw, Yan Guo, Linbo Gao, Cao Zl |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult Risk medicine.medical_specialty Genotype Single-nucleotide polymorphism MiRNA binding Breast Neoplasms Biology medicine.disease_cause Polymorphism Single Nucleotide Proto-Oncogene Proteins p21(ras) Breast cancer Gene Frequency Internal medicine Genetics medicine Odds Ratio Humans Genetic Predisposition to Disease Molecular Biology Allele frequency 3' Untranslated Regions Alleles Genetic Association Studies Aged Neoplasm Staging Binding Sites Case-control study General Medicine Middle Aged medicine.disease Genotype frequency MicroRNAs Case-Control Studies Cancer research Female KRAS Neoplasm Grading |
| Zdroj: | Genetics and molecular research : GMR. 14(4) |
| ISSN: | 1676-5680 |
| Popis: | Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 polymorphism, and evaluate its effect on BC risk. This hospital-based case-control study comprised 228 patients with histologically confirmed BC and 251 healthy controls. The let-7a KRAS rs712 polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism. We observed no statistically significant association between BC risk and the let-7a KRAS rs712 polymorphism (GT vs GG, OR = 0.98, 95%CI = 0.66-1.46; TT vs GG, OR = 0.78, 95%CI = 0.28-2.21). However, the rs712 polymorphism was significantly associated with the N status of BC patients (GG vs GT/TT, OR = 0.52, 95%CI = 0.30- 0.92; G allele vs T allele, OR = 0.60, 95%CI = 0.37-0.97). We found no association between the let-7 rs712 polymorphism and BC risk. However, the let-7 rs712 G/T polymorphism was discovered to play a potential role in BC tumor metastasis; therefore, it may be employed as a new biomarker or therapy targeted towards resistant tumor metastasis. |
| Databáze: | OpenAIRE |
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