Effects of the novel antidepressant S-adenosyl-methionine on α1- and β-adrenoceptors in rat brain
| Autor: | Ana L. Sosa, Vincenzo R. Olgiati, Suzann M. Babb, Bruce M. Cohen, Giorgio Stramentinoli |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Agonist Imipramine S-Adenosylmethionine medicine.medical_specialty medicine.drug_class In Vitro Techniques Pharmacology Reuptake chemistry.chemical_compound Internal medicine Receptors Adrenergic beta medicine Animals S-Adenosyl methionine Receptor Phenylephrine Brain Chemistry Rats Inbred Strains Receptors Adrenergic alpha Antidepressive Agents Rats Kinetics Endocrinology Monoamine neurotransmitter chemistry Antidepressant medicine.drug |
| Zdroj: | European Journal of Pharmacology. 170:201-207 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(89)90540-2 |
| Popis: | alpha 1- and beta-adrenoceptors were studied ex vivo in the brains of rats receiving repeated daily treatment with the standard antidepressant imipramine or the atypical antidepressant S-adenosyl-L-methionine (SAM), which has minimal effects on monoamine reuptake or turnover. Consistent with past studies, a decrease in the density of beta receptors at three weeks and an increase in the affinity of alpha 1 receptors for the agonist phenylephrine at one week of treatment was observed with imipramine. By comparison, an increase in the density of beta receptors and a decrease in the affinity of alpha 1 receptors for phenylephrine was observed at one week of treatment with SAM. These changes were no longer apparent at three weeks of treatment. The results suggest that treatment with SAM does lead to changes in adrenergic neurotransmission, but that down regulation of beta receptors or increased agonist affinity of alpha 1 receptors may not be necessary for the production of antidepressant effects. |
| Databáze: | OpenAIRE |
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