Effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats
| Autor: | Xue-Ping Han, Lin-Bo Liu, Ying-Ping Jia, Jian-Hao Yang, Zheng-Chen Li, Yue-Lan Zhang, Wu Zhang, Wei-Dong Kong |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Molar medicine.medical_specialty Periodontal tissue Tooth Movement Techniques Dentistry Inflammation Group A Group B Rats Sprague-Dawley Orthodontic tooth movement Internal medicine Animals Humans Inflammatory periodontal tissue Medicine Interleukin 8 Interleukin 6 Periodontal Diseases Medicine(all) biology Interleukin-6 business.industry Interleukin-8 Tooth Migration General Medicine Biomechanical Phenomena Rats Endocrinology biology.protein Immunohistochemistry Stress Mechanical medicine.symptom business |
| Zdroj: | Asian Pacific Journal of Tropical Medicine. 6:757-761 |
| ISSN: | 1995-7645 |
| DOI: | 10.1016/s1995-7645(13)60133-9 |
| Popis: | ObjectiveTo investigate effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats.MethodsEighty SD rats were randomly divided into 4 groups, blank control group (group A) with 5 rats, treatment normal group (group B) with 25 rats, inflammation control group (group (group C) with 25 rats, inflammation treatment group (group D) with 25 rats. Immunohistochemistry and histomorphometric analysis was performed to measure the expression of IL-6, IL-8 and the first molar to the recent movement in the distance.ResultsThe expression of IL-8 reached a maximum on day 5 and declined thereafter in group B; the expression of IL-6 reached a maximum on day 5 in group B. The expression of IL-6 and IL-8 was gradually weakened with time in group C. The expression of IL-6 and IL-8 were high, and reached a maximum on day 5 and declined thereafter in group D. AD of positive cells in group D were higher than group B at each time point (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|