Synthesis of the 3,5-diphenyl-1H-pyrazole and cytogenetic and oxidative alterations after exposure of cultured human whole blood cells
| Autor: | Erdem Ergan, Hasan Turkez, Adem Ruzgar, Ozlem Ozdemir, Ertan Şahin, Esvet Akbas, Fatih Çağlar Çelikezen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Dibenzoylmethane
010405 organic chemistry General Engineering Oxidative phosphorylation Pyrazole 010402 general chemistry Condensation reaction thiosemicarbazide 01 natural sciences 0104 chemical sciences pyrazole lcsh:Chemistry Acetic acid chemistry.chemical_compound cytotoxic chemistry lcsh:QD1-999 Microwave irradiation Organic chemistry lcsh:Q lcsh:Science Whole blood |
| Zdroj: | Cogent Chemistry, Vol 3, Iss 1 (2017) |
| ISSN: | 2331-2009 |
| Popis: | The 3,5-diphenyl-1H-pyrazole was obtained by condensation reaction of dibenzoylmethane and thiosemicarbazide in acetic acid under conventional heating and microwave irradiation method. The structure of the 3,5-diphenyl-1H-pyrazole confirmed by IR, H-1, and C-13 NMR and X-ray diffraction and the geometry optimization was carried out using density functional theory (DFT) methods at B3LYP/6-31G, 6-31G(d), 6-31G(d, p), 6-311G(d, p), 6-311G(2d, 2p), 6-31+G(d, p), 6-311++G(d, p) levels. In addition, cytotoxic and oxidative effects were investigated in cultured human peripheral blood cells. |
| Databáze: | OpenAIRE |
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