Molecular Cloning, mRNA Expression and Chromosomal Localization of Mouse Angiotensin-converting Enzyme-related Carboxypeptidase (mACE2)

Autor:	Sawako Muroi, Munetomo Hida, Jun-ichi Imai, Kazuo Hanaoka, Akira Tanigami, Takami Komatsu, Yutaka Suzuki, Yoshitsugu Yamada, Sumio Sugano
Rok vydání:	2002
Předmět:	Molecular Sequence Data Carboxypeptidases Peptidyl-Dipeptidase A Molecular cloning Kidney Biochemistry Gene Expression Regulation Enzymologic Mice Open Reading Frames Endocrinology Complementary DNA Genetics Animals Humans Tissue Distribution Amino Acid Sequence Northern blot Cloning Molecular Lung Molecular Biology Peptide sequence Gene Chromosomes Human X Base Sequence Sequence Homology Amino Acid biology Reverse Transcriptase Polymerase Chain Reaction Alternative splicing Chromosome Mapping Blotting Northern Carboxypeptidase Molecular biology biology.protein Angiotensin-Converting Enzyme 2 Sequence motif Sequence Alignment hormones hormone substitutes and hormone antagonists
Zdroj:	DNA Sequence. 13:217-220
ISSN:	1042-5179
Popis:	We isolated two mouse cDNA clones which show significant similarities with human angiotensin-converting enzyme-related carboxypeptidase (ACE2). The cDNAs were 2746 and 1995 bp in length and seemed to arise from the same gene by alternative splicing. The longer cDNA encoded a 798-amino acid protein containing the sequence motif conserved among zinc metallopeptidases. Mouse ACE2 showed 83% identity with human ACE2. Northern blot analysis revealed that 2.8- and 2.0-kb transcripts were expressed mainly in the kidney and the lungs. The mouse ACE2 gene was mapped to chromosome X 70.5 cM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7ff89425f1aa01ef04f7ddd7a61832 https://doi.org/10.1080/1042517021000021608 Zobrazit plný text záznamu Plný text ve formátu PDF