Can Differences in Vascularity Serve as a Diagnostic Aid in Fibro-Osseous Lesions of the Jaws?
| Autor: | Ilana Kaplan, Tom Shmuly, Gavriel Chaushu, Dror M. Allon, Benjamin Shlomi, Marilena Vered |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Biopsy Predictor variables Diagnostic aid Perimeter 03 medical and health sciences 0302 clinical medicine Vascularity medicine Humans Cementoma medicine.diagnostic_test business.industry Fibrous dysplasia Central ossifying fibroma Fibrous Dysplasia of Bone 030206 dentistry Anatomy medicine.disease Jaw Neoplasms Cross-Sectional Studies Otorhinolaryngology Dysplasia 030220 oncology & carcinogenesis Fibroma Ossifying Female Surgery Oral Surgery medicine.symptom Nuclear medicine business Jaw Diseases |
| Zdroj: | Journal of Oral and Maxillofacial Surgery. 75:1201-1208 |
| ISSN: | 0278-2391 |
| DOI: | 10.1016/j.joms.2016.11.017 |
| Popis: | Purpose Different lesions in the fibro-osseous group share microscopic features; thus, establishing a definitive diagnosis based on microscopic features alone can be a challenge. There is a need for additional microscopic tools to aid in differentiating these lesions. This study compared parameters related to vascularity among 3 lesions in the fibro-osseous group: fibrous dysplasia (FD), central ossifying fibroma (COF), and cemento-osseous dysplasia (COD). Materials and Methods This study was a cross-sectional analysis of biopsied lesions retrieved from 3 medical centers over a 14-year period. The primary predictor variables were the vascularity parameters (number, perimeter, and area). The outcome variables were diagnoses of FD, COF, and COD. Diagnosis was based on clinical, microscopic, and radiologic correlations. From each histopathologic slide, 5 representative fields were captured with a computerized digital camera. The number of blood vessels was counted, and the surface area and vascular perimeter were measured by tracing the perimeter of each vessel. Data were statistically analyzed using analysis of variance with logarithmic transformation and a Tukey adjustment. Results Sixty-six cases were included in the study (26 in FD group, 26 in COF group, and 14 in COD group). The mean number of vessels showed only a tendency to be larger in the FD group compared with the COF and COD groups (5.4 ± 2.6, 3.7 ± 2.3, and 3.6 ± 1.7, respectively), but the results did not reach the threshold for significance. The mean vascular perimeter was 1,385.8 ± 859.2 pixels in the FD group and 742.6 ± 661.8 in COF group after logarithmic transformation (P = .012). The perimeter in the COD group was smaller (941.1 ± 502) compared with that in the FD group, but the difference did not reach the threshold for significance. The mean area was 25,061 ± 24,875.6 in the FD group and 11,773.8 ± 21,734.4 in the COF group after logarithmic transformation (P = .004). The perimeter in the COD group was smaller (13,011.1 ± 8,338.3) compared with the FD group, but the difference did not reach the threshold for significance. Conclusion The vascular content of the FD group was markedly higher than of the COF group. These vascular changes can aid in differentiating these lesions microscopically. |
| Databáze: | OpenAIRE |
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