PP057. The role of uterine artery pulsatility index for prediction of pregnancy outcome, in women affected by pre-eclampsia

Autor: C. Platto, Tiziana Frusca, M. Gregorini, P.L. Rovida, Giorgio Pagani, Adriana Valcamonico, Andrea Lojacono, V. Gerosa
Rok vydání: 2012
Předmět:
Zdroj: Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 2:272-273
ISSN: 2210-7789
DOI: 10.1016/j.preghy.2012.04.168
Popis: Introduction Uterine artery (UtA) Pulsatility index assessed in the second trimester is known to be the best predictor of Pre-eclampsia (PE) in women with risk factors. The role of this index when PE occurs seems to be related with clinical outcome. Objectives To detect if there does exist a correlation between mean UtA PI, assessed at diagnosis of PE, and: (A) Gestational Age (GA) at delivery; (B) birth weight (BW) percentile. To detect the predictive value of mean UtA PI and the development of adverse pregnancy outcome (APO). Methods Cohort study on 100 consecutive singleton pregnancies complicated with pre-eclampsia referred to our Department from January 2010 and December 2011. Doppler evaluations were performed from diagnosis to delivery. Mean UtA PI obtained at time of diagnosis of PE were analysed. PE was defined according to ISSHP criteria. Clinical and perinatal outcomes were reviewed. APO was defined as Apgar score less than 7 at five minutes, pH Results Maternal characteristics and main pregnancy outcomes are shown in Table 1. Fifty-six pregnancies developed APO. One case of stillbirth and four cases of neonatal death were observed. SGA occurred in 56/100 neonates; 52/95 (55%) live births were admitted to Neonatal Intensive Care Unit. Table 1. MinimumMaximumMeanSDMaternal Age (yy)2044335BMI (kg/mq)164623.574.93GA at diagnosis of PE (w)23+039+432+53+6GA at delivery (w)23+239+433+43+4Birth Weight (g)037101794.01769.59BW percentile0.0073.2013.3318.28pH6.807.387.260.11 Mean UtA PI at diagnosis of PE was 1.40 (SD±0.28) in women that developed APO and 1.10 (SD±0.41) in women that did not develop APO ( p =0.02). Pearson's Correlation coefficient for mean UtA PI and GA at Delivery was -0.533 ( p =0.002); while for mean UtA PI and BW percentile was -0.466 ( p =0.007). The prediction of subsequent development of APO, expressed as the area under ROC curve, was 61.6 (95% CI 0.44–0.79) for UtA PI at Diagnosis of PE. Conclusion Our data confirm that mean UtA PI, assessed at diagnosis of PE, represent a good independent predictor for GA at delivery end BW percentile. However the predictive value for development of APO seems to be poor.
Databáze: OpenAIRE
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