Segmental arterial mediolysis and fibromuscular dysplasia: what comes first, the chicken or the egg?
| Autor: | Paola Devis, Blake A. Gibson, E. Tyler Hall, Stacey Black, Charles Hennemeyer, Brandon T. Larsen |
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| Rok vydání: | 2016 |
| Předmět: |
Tunica media
Pathology medicine.medical_specialty Fatal outcome Fibromuscular dysplasia 030204 cardiovascular system & hematology Pathology and Forensic Medicine Pathogenesis 03 medical and health sciences Fatal Outcome 0302 clinical medicine medicine.artery medicine Fibromuscular Dysplasia Humans Vascular Diseases Aorta business.industry Intraabdominal hemorrhage General Medicine Anatomy Middle Aged medicine.disease Segmental arterial mediolysis medicine.anatomical_structure 030220 oncology & carcinogenesis cardiovascular system Female Tunica Media Cardiology and Cardiovascular Medicine Splanchnic business |
| Zdroj: | Cardiovascular Pathology. 25:113-115 |
| ISSN: | 1054-8807 |
| Popis: | Segmental arterial mediolysis (SAM) is a rare vasculopathy characterized by lysis of the outer media in splanchnic arteries and formation of dissecting pseudoaneurysms that may spontaneously rupture, leading to massive and often fatal intraabdominal hemorrhage. The pathogenesis of SAM is poorly understood. Healed SAM lesions closely resemble fibromuscular dysplasia (FMD), leading some authors to postulate that SAM represents a precursor to FMD despite distinct clinical differences between these two disorders. Herein, we present a 61-year-old woman with fatal SAM who showed histologic features in her aorta suggesting the opposite pathogenetic relationship, with an unclassified "FMD-like" arteriopathy preceding development of SAM. |
| Databáze: | OpenAIRE |
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