Association between age at antiretroviral therapy initiation and 24-month immune response in West-African HIV-infected children
| Autor: | Desmonde, Sophie, Dicko, Fatoumata, Koueta, Fla, Eboua, Tanoh, Balestre, Eric, Amani-Bosse, Clarisse, Aka, Edmond A, Lawson-Evi, Koko, Amorissani-Folquet, Madeleine, Kouakou, Kouadio, Koumakpai, Siriatou, Renner, Lorna, Signaté Sy, Haby, Leroy, Valériane, Sodemann, Morten |
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| Přispěvatelé: | Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), MTCT-Plus programme (ACONDA), MTCT-Plus programme, Université Lumière - Lyon 2 (UL2), École Nationale des Travaux Publics de l'État (ENTPE), École Nationale des Travaux Publics de l'État (ENTPE)-Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Matière et Systèmes Complexes (MSC (UMR_7057)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement-École Nationale des Travaux Publics de l'État (ENTPE), Recherches Translationnelles sur le VIH et les maladies infectieuses (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Université de Montpellier (UM), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Pediatrics medicine.medical_specialty [SDV]Life Sciences [q-bio] 030231 tropical medicine Immunology Population HIV Infections Article 03 medical and health sciences 0302 clinical medicine Sex Factors West Africa medicine Immunology and Allergy Humans 030212 general & internal medicine education Child Children Survival analysis Immunodeficiency ComputingMilieux_MISCELLANEOUS education.field_of_study biology business.industry Hazard ratio Age Factors Infant HIV Immune reconstitution medicine.disease Confidence interval CD4 Lymphocyte Count Antiretroviral therapy Regimen Africa Western Infectious Diseases Treatment Outcome Anti-Retroviral Agents Child Preschool Cohort biology.protein Female [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Antibody business |
| Zdroj: | AIDS AIDS, Lippincott, Williams & Wilkins, 2014, 28 (11), pp.1645-55. ⟨10.1097/QAD.0000000000000272⟩ Desmonde, S, Dicko, F, Koueta, F, Eboua, T, Balestre, E, Amani-Bosse, C, Aka, E A, Lawson-Evi, K, Amorissani-Folquet, M, Kouakou, K, Koumakpai, S, Renner, L, Signaté Sy, H, Leroy, V & IeDEA West Africa Paediatric Collaboration (Christian Erikstrup, Alex Laursen, Christian Wejse, Lars Østergaard; members) 2014, ' Association between age at antiretroviral therapy initiation and 24-month immune response in West-African HIV-infected children ', AIDS, vol. 28, no. 11, pp. 1645-55 . https://doi.org/10.1097/QAD.0000000000000272 Desmonde, S, Dicko, F, Koueta, F, Eboua, T, Balestre, E, Amani-Bosse, C, Aka, E A, Lawson-Evi, K, Amorissani-Folquet, M, Kouakou, K, Koumakpai, S, Renner, L, Signaté Sy, H, Leroy, V, IeDEA West Africa Paediatric Collaboration & Sodemann, M 2014, ' Association between age at antiretroviral therapy initiation and 24-month immune response in West-African HIV-infected children ', AIDS, vol. 28, no. 11, pp. 1645-1655 . https://doi.org/10.1097/QAD.0000000000000272 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/QAD.0000000000000272⟩ |
| Popis: | OBJECTIVE: We describe the association between age at antiretroviral therapy (ART) initiation and 24-month CD4 cell response in West African HIV-infected children.METHODS: All HIV-infected children from the IeDEA paediatric West African cohort, initiating ART, with at least two CD4 cell count measurements, including one at ART initiation (baseline) were included. CD4 cell gain on ART was estimated using a multivariable linear mixed model adjusted for baseline variables: age, CD4 cell count, sex, first-line ART regimen. Kaplan-Meier survival curves and a Cox proportional hazards regression model compared immune recovery for age within 24 months post-ART.RESULTS: Of the 4808 children initiated on ART, 3014 were enrolled at a median age of 5.6 years; 61.2% were immunodeficient. After 12 months, children at least 4 years at baseline had significantly lower CD4 cell gains compared with children less than 2 years, the reference group (PCONCLUSION: These results suggest that both the initiation of ART at the earliest age less than 5 years and before any severe immunodeficiency is needed for improving 24-month immune recovery on ART. |
| Databáze: | OpenAIRE |
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