Deconstructing cortical folding: genetic, cellular and mechanical determinants
| Autor: | Víctor Borrell, Cristina Llinares-Benadero |
|---|---|
| Přispěvatelé: | European Commission, Ministerio de Economía y Competitividad (España), European Research Council, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Consejo Superior de Investigaciones Científicas (España) |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cerebral Cortex Neurons General Neuroscience Neurogenesis Biological evolution Biology Mammalian brain Biological Evolution Folding (chemistry) 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Experimental testing Cerebral cortex Cell Movement medicine Animals Humans Neuroscience Neuroglia 030217 neurology & neurosurgery |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1471-0048 |
| Popis: | Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and is associated with dramatic increases in size and complexity. New animal models, genetic tools and bioengineering materials have moved the study of cortical folding from simple phenomenological observation to sophisticated experimental testing. Here, we provide an overview of how genetics, cell biology and biomechanics shape this complex and multifaceted process and affect each other. We discuss the evolution of cortical folding and the genomic changes in the primate lineage that seem to be responsible for the advent of larger brains and cortical folding. Emerging technologies now provide unprecedented tools to analyse and manipulate cortical folding, with the promise of elucidating the mechanisms underlying the stereotyped folding of the cerebral cortex in its full complexity. The authors’ research was supported by a European Research Grant (CORTEXFOLDING-309633), a Spanish Ministry of Economy and Competitiveness Grant (SAF2015-69168-R), the European Union Seventh Framework Programme (FP7/2007-2013, under the project DESIRE-602531) and the Spanish State Research Agency through the ‘Severo Ochoa’ Programme for Centers of Excellence in Research and Development (reference SEV-2017-0723). |
| Databáze: | OpenAIRE |
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