The prevalence of factor V Leiden mutation in patients with leg ulcers and venous insufficiency
| Autor: | K. Hamulyak, D. J. Tazelaar, M. B. Maessen-Visch, N. H. C. M. N. Crombag, H. A. M. Neumann |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Chronic venous insufficiency Population Dermatology Gastroenterology Polymerase Chain Reaction Gene Frequency Internal medicine Factor V Leiden Coagulopathy Prevalence Medicine Humans Point Mutation education Aged Aged 80 and over education.field_of_study business.industry Leg Ulcer Case-control study Factor V General Medicine DNA Middle Aged medicine.disease Dyskeratosis Surgery Venous thrombosis Venous Insufficiency Case-Control Studies Chronic Disease Female Factor V Leiden mutation business |
| Zdroj: | Archives of dermatology. 135(1) |
| ISSN: | 0003-987X |
| Popis: | Objectives To study the prevalence of factor V Leiden mutation in patients with chronic venous insufficiency and venous leg ulcers, compared with a control group, and to find out whether factor V Leiden mutation is more frequent in patients with chronic venous insufficiency and a history of deep venous thrombosis. Design A case control study. Setting Three outpatient dermatological clinics. Patients Ninety-two patients (37 men, 55 women) with venous leg ulcers and 53 control patients (23 men, 30 women). Main Outcome Measure Factor V Leiden mutation. Results Factor V Leiden mutation was significantly more frequent in patients with chronic venous insufficiency and venous leg ulcers than in the control group (23% vs 7.5%; P =.03), and the patients with factor V Leiden mutation were more likely to have a history of venous thromboembolism (91% vs 48%, P =.002). Also, recurrent deep venous thrombosis (38% vs 14%) and recurrent leg ulcerations (9 episodes or more) occurred more frequently in the patients with factor V Leiden mutation (43% vs 19%, P =.01). No difference was observed in venous refill time or in the presence of dermatoliposclerosis and atrophie blanche. Conclusions Factor V Leiden mutation is more frequent in patients with venous leg ulceration than in the control group and the general population. Patients with factor V Leiden mutation have an increased risk of developing deep venous thrombosis and recurrent leg ulceration. |
| Databáze: | OpenAIRE |
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