Executive dysfunction in early stages of Huntington's disease is associated with striatal and insular atrophy: A neuropsychological and voxel-based morphometric study
| Autor: | Jan Kassubek, Thomas Jahn, Adolf Weindl, Alexander Peinemann, Sabine Schuller, Corina Pohl |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Neuropsychological Tests Audiology Statistical parametric mapping Cognition Atrophy Huntington's disease Predictive Value of Tests Image Processing Computer-Assisted medicine Humans Cerebral Cortex Brain Mapping Cognitive disorder Putamen Neuropsychology Voxel-based morphometry Middle Aged medicine.disease Magnetic Resonance Imaging Corpus Striatum Huntington Disease Neurology Disease Progression Female Neurology (clinical) Caudate Nucleus Cognition Disorders Psychology Executive dysfunction Stroop effect |
| Zdroj: | Journal of the Neurological Sciences. 239:11-19 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2005.07.007 |
| Popis: | Background Huntington's disease (HD) is characterized by a progressive multisystem neuronal atrophy in the brain. Apart from motor signs, cognitive symptoms, particularly executive dysfunctions, are proposed to be recognizable in early stages of disease. The aim of the present study was to clarify if cognitive dysfunction in early stages of HD is correlated with loco-regional structural changes in 3D-MRI. Methods Twenty-five patients with genetically confirmed HD in early clinical stages were included in the study and underwent neuropsychological testing, i.e., the executive tasks Tower of Hanoi (ToH), Stroop Colour Word Interference Test (STROOP), and modified Wisconsin Card Sorting Test (mWCST). High-resolution volume-rendering MRI scans (MP-RAGE) were acquired on a 1.5 T scanner in all patients and were analyzed by statistical parametric mapping and voxel-based morphometry (VBM) in comparison to an age-matched control group. Results Group analysis of HD patients demonstrated robust regional decreases of gray matter volumes (p |
| Databáze: | OpenAIRE |
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