Inducible nitric oxide synthase in innate immune cells is important for restricting cyst formation of Toxoplasma gondii in the brain but not required for the protective immune process to remove the cysts
| Autor: | Yasuhiro Suzuki, Eri Ochiai, Jeremi Mullins, Qila Sa, Ashish Tiwari |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Phagocyte Immunology Nitric Oxide Synthase Type II Mice SCID CD8-Positive T-Lymphocytes Microbiology Article Mice 03 medical and health sciences 0302 clinical medicine Immune system Phagosomes parasitic diseases medicine Animals Cytotoxic T cell Cyst Mice Inbred BALB C Innate immune system biology Brain Toxoplasma gondii Chloroquine biology.organism_classification medicine.disease Immunity Innate Nitric oxide synthase Toxoplasmosis Animal 030104 developmental biology Infectious Diseases medicine.anatomical_structure biology.protein Female Toxoplasma CD8 030215 immunology |
| Zdroj: | Microbes and Infection. 20:261-266 |
| ISSN: | 1286-4579 |
| DOI: | 10.1016/j.micinf.2017.12.004 |
| Popis: | Significantly larger numbers of Toxoplasma gondii cysts were detected in the brains of RAG1−/−NOS2−/− than RAG1−/− mice following infection. In contrast, the cyst numbers markedly decreased in a same manner in both strains of mice after receiving CD8+ immune T cells. Thus, NOS2-mediated innate immunity is important for inhibiting formation of cysts in the brain but not required for the T cell-initiated cyst removal, which is associated with phagocyte accumulation. Treatment with chloroquine, an inhibitor of endolysosomal acidification, partially but significantly inhibited the T cell-mediated cyst removal, suggesting that phagosome–lysosome fusion could be involved in the T. gondii cyst elimination. |
| Databáze: | OpenAIRE |
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