Immune modulation of blood leukocytes in humans by lactic acid bacteria: criteria for strain selection
| Autor: | Eduardo Schiffrin, Dominique Brassart, Alain L. Servin, A Donnet-Hughes, Florence Rochat |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Lymphocyte ved/biology.organism_classification_rank.species Medicine (miscellaneous) medicine.disease_cause Bacterial Adhesion Cell Line law.invention Microbiology Feces Probiotic chemistry.chemical_compound Lactobacillus acidophilus Immune system Phagocytosis Species Specificity law Escherichia coli Leukocytes medicine Animals Humans Nutrition and Dietetics Bifidobacterium bifidum biology ved/biology food and beverages Middle Aged biology.organism_classification Lymphocyte Subsets Lactic acid Milk medicine.anatomical_structure chemistry Immunology Microscopy Electron Scanning Female Bifidobacterium Bacteria |
| Zdroj: | The American Journal of Clinical Nutrition. 66:515S-520S |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/66.2.515s |
| Popis: | Lactic acid bacteria in food can transiently colonize the intestine and exert beneficial effects (probiotic). Survival during intestinal transit or adhesion to epithelium or both seem to be important for modifying the host's immune reactivity. Because Lactobacillus acidophilus strain La1 is adherent to enterocytes in vitro, we hypothesize that contact with immune cells may occur in vivo. However, Bifidobacterium bifidum strain Bb12, which shows high fecal colonization, is another potential immunomodulator. Twenty-eight volunteers were divided into two groups and given a fermented product containing one of the two strains. Lymphocyte subsets and leukocyte phagocytic activity were studied in blood. No modifications were detected in lymphocyte subsets. In contrast, phagocytosis of Escherichia coli ssp. was enhanced in both groups (P < 0.001 for both). Bacterial adhesion to enterocytes, fecal colonization, or both seem to be valuable selection criteria for immunomodulation. Antiinfective mechanisms of defense can be enhanced after ingestion of specific lactic acid bacteria strains. |
| Databáze: | OpenAIRE |
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