Pathogenesis of pelvic pain syndrome associated with endometriosis in patients resistant to surgical treatment

Autor:	M.B. Khamoshina, Victor E. Radzinsky, Mekan R. Orazov, Olga Sharapova
Rok vydání:	2020
Předmět:	Adult Pelvic pain syndrome medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Endometriosis Apoptosis 030209 endocrinology & metabolism Pelvic Pain Peritoneal Diseases Russia Pathogenesis Young Adult 03 medical and health sciences Gynecologic Surgical Procedures 0302 clinical medicine Endocrinology Recurrence Surveys and Questionnaires medicine Humans In patient Treatment Failure Surgical treatment Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Pelvic pain Obstetrics and Gynecology Syndrome Middle Aged medicine.disease Surgery body regions Case-Control Studies Female Neurogenic Inflammation medicine.symptom business human activities Follow-Up Studies
Zdroj:	Gynecological Endocrinology. 36:12-15
ISSN:	1473-0766 0951-3590
DOI:	10.1080/09513590.2020.1816721
Popis:	Endometriosis is one of the most common gynecological diseases diagnosed in almost 70% of patients with chronic pelvic pain (CPP). However, a quarter of women with pelvic pain is diagnosed with external genital endometriosis (EGE) during laparoscopy. A special group is represented by patients with PP that did not stop after the removal of endometrial foci. The mechanisms of the pathogenesis of the formation of pain syndrome are not completely explored yet. According to several authors, a significant role in the pathogenesis of pelvic pain recurrence after surgical treatment of EGE is played by active neuroangiogenesis, both in ectopic and eutopic endometrium. The aim of the study was to expand the understanding of the pathogenesis of pelvic pain that did not stop (recurrence) after surgical treatment of external genital endometriosis.The study involved 2 stages. At the first stage (algological), data from BB, NRS and VRS algological questionnaires, which were completed by patients with recurrent PP after surgical treatment of EGE, were analyzed (The results of the study have shown that the basis of pathogenesis of pelvic pain recurrence in patients who did not receive medical therapy after surgical treatment of EGE is the activation of neuro-angiogenesis processes and reduction of apoptosis. The results show a statistically significant 1.6 times increasing expression of NGF in eutopic endometrium (57.9 ± 2.5 vs 35.3 ± 2.1% of patients with the silent form of the gene and its receptor NTRK1 1.8 times (2.78 ± 0.25 versus 1.56 ± 0.21.e. respectively).
Databáze:	OpenAIRE
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