SARS-CoV-2 Vaccination: The Time Is Now
| Autor: | Joshua J. Wiegel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
education.field_of_study
medicine.medical_specialty COVID-19 Vaccines Transmission (medicine) business.industry SARS-CoV-2 medicine.medical_treatment Population Vaccination Antibody titer Outbreak COVID-19 Immunosuppression General Medicine Antibodies Viral Herd immunity Editorial Internal medicine medicine Humans education business Dialysis |
| Zdroj: | Kidney360 |
| Popis: | March 2020 marked the beginning of unprecedented times. Pandemic-related lockdowns, government shutdowns, outbreaks, overloaded health care systems, and the resultant debates regarding masking, social distancing, political divides, and outright madness has become the hallmark of the past year and a half. Vaccination and the elusive “herd immunity” was a glowing point on the horizon, signaling the return to normalcy. However, for many, the promise of a vaccine preventing transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the development of severe coronavirus disease 2019 (COVID-19) have fallen short. Immunocompromised individuals, including transplant recipients on immunosuppressive medications, have been found to have significantly lower rates of SARS-CoV-2 spike protein antibody positivity than the general population after receiving a vaccination of any of the available products (1⇓⇓⇓–5). Additionally, those who do have a positive response tend to have much lower antibody titers compared with the general population. In this issue, Kolb and colleagues describe their experience with mRNA vaccine responses in kidney transplant recipients (KTRs) and patients with ESKD on dialysis compared with controls. Similar to previous reports, they found significantly reduced SARS-CoV-2 spike S1–specific IgG titers in KTRs compared with an immunocompetent comparator (6,7). Interestingly, the patients with ESKD also had significantly improved responses over KTRs, despite their perceived degree of functional immunosuppression. To … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|