The role of the peroxisome proliferator-activated receptor-α (PPAR-α) in the regulation of acute inflammation
| Autor: | Cuzzocrea, Salvatore, Mazzon, E, DI PAOLA, R, Peli, A, Bonato, A, Britti, D, Genovese, Tiziana, Muia, C, Crisafulli, Concetta, Caputi, Achille, DI PAOLA, Rosanna |
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| Přispěvatelé: | Cuzzocrea S., Mazzon E., Di Paola R., Peli A., Bonato A., Britti D., Genovese T., Muia` C., Crisafulli C., and Caputi A. P. |
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Fas Ligand Protein Immunology Peroxisome proliferator-activated receptor Inflammation Biology Carrageenan Fas ligand Mice Internal medicine NEUTROPHIL INFILTRATION medicine Animals Edema Immunologic Factors Immunology and Allergy PPAR alpha Receptor Lung Pleurisy Mice Knockout chemistry.chemical_classification CARRAGEENAN-INDUCED PAW EDEMA Membrane Glycoproteins Thyroid hormone receptor Foot Tumor Necrosis Factor-alpha CYTOKINES Cell Biology Up-Regulation Chemotaxis Leukocyte Disease Models Animal Endocrinology Nuclear receptor chemistry CARRAGEENAN-INDUCED Acute Disease Tumor Necrosis Factors Knockout mouse Female Tumor necrosis factor alpha Inflammation Mediators medicine.symptom Interleukin-1 Signal Transduction |
| Zdroj: | Journal of Leukocyte Biology. 79:999-1010 |
| ISSN: | 1938-3673 0741-5400 |
| Popis: | The peroxisome proliferator-activated receptor-α (PPAR- α) is a member of the nuclear receptor superfamily of ligand-dependent transcription factors related to retinoid, steroid, and thyroid hormone receptors. The aim of the present study was to evaluate the role of the PPAR- α receptor on the development of acute inflammation. To address this question, we used two animal models of acute inflammation (carrageenan-induced paw edema and carrageenan-induced pleurisy). We report here that when compared with PPAR- α wild-type mice, PPAR- α knockout mice (PPAR- α KO) mice experienced a higher rate of the extent and severity when subjected to carrageenan injection in the paw edema model or to carrageenan administration in the pleurisy model. In particular, the absence of a functional PPAR- α gene in PPAR- α KO mice resulted in a significant augmentation of various inflammatory parameters (e.g., enhancement of paw edema, pleural exudate formation, mononuclear cell infiltration, and histological injury) in vivo. Furthermore, the absence of a functional PPAR- α gene enhanced the staining (immunohistochemistry) for FAS ligand in the paw and in the lung and the expression of tumor necrosis factor α and interleukin-1β in the lungs of carrageenan- treated mice. In conclusion, the increased inflammatory response observed in PPAR- αKO mice strongly suggests that a PPAR- α pathway modulates the degree of acute inflammation in the mice. |
| Databáze: | OpenAIRE |
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