Short-term treatment with growth hormone stimulates osteoblastic and osteoclastic activity in osteopenic postmenopausal women: a dose response study
Autor: | Henning K. Nielsen, Anne Gitte Loft, Moustapha Kassem, Kim Brixen, Leif Mosekilde, Allan Flyvbjerg |
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Rok vydání: | 1995 |
Předmět: |
Procollagen/blood
Deoxypyridinoline Osteoclasts/cytology Endocrinology Diabetes and Metabolism Bone Development/drug effects Parathyroid hormone Osteoclasts Bone remodeling chemistry.chemical_compound Bone Density Insulin Orthopedics and Sports Medicine Insulin-Like Growth Factor I Osteoporosis Postmenopausal Bone mineral Pyridinoline Osteocalcin/blood Middle Aged Bone Resorption/drug therapy Bone Diseases Metabolic/drug therapy Insulin-Like Growth Factor I/metabolism Female Procollagen medicine.medical_specialty Thyroid Hormones Injections Subcutaneous Osteocalcin Bone resorption N-terminal telopeptide Calcitriol Internal medicine medicine Humans Bone Resorption Calcitriol/blood Aged Bone Development Osteoblasts Dose-Response Relationship Drug business.industry Osteoporosis Postmenopausal/drug therapy Osteoblasts/cytology Bone Density/drug effects medicine.disease Thyroid Hormones/blood Peptide Fragments Osteopenia Bone Diseases Metabolic Endocrinology Growth Hormone/administration & dosage chemistry Growth Hormone Insulin/blood Peptide Fragments/blood business Biomarkers/blood Biomarkers |
Zdroj: | Brixen, K, Kassem, M, Nielsen, H K, Loft, A G, Flyvbjerg, A & Mosekilde, L 1995, ' Short-term treatment with growth hormone stimulates osteoblastic and osteoclastic activity in osteopenic postmenopausal women : a dose response study ', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 10, no. 12, pp. 1865-74 . https://doi.org/10.1002/jbmr.5650101205 |
ISSN: | 0884-0431 |
Popis: | To investigate the potential use of growth hormone (GH) in Activate-Depress-Free-Repeat treatment of postmenopausal osteoporosis, we measured changes in serum levels of biochemical markers of bone turnover, insulin-like growth factor-I (IGF-I), calciotropic hormones, and bone mineral density in 40 postmenopausal women with osteopenia (ages 52-73 years) in response to 7 days of treatment with either placebo or GH (0.05, 0.10, or 0.20 IU/kg/day) administered subcutaneously in the evening. GH treatment increased serum osteocalcin (p < 0.01) and C-terminal type-I procollagen propeptide (p < 0.01) and also serum levels of type-I collagen telopeptide (p < 0.001), fasting urinary hydroxyproline/creatinine (p < 0.05), pyridinoline/creatinine (p < 0.05), and deoxypyridinoline/creatinine (p < 0.01) in a dose-dependent fashion. Even the lowest dose of GH tested induced a significant increase in these parameters; however, the effects were transient lasting only 1-2 weeks. In the highest dose group, however, a somewhat prolonged effect (30 days) on serum osteocalcin was observed. Furthermore, GH increased serum levels of IGF-I, insulin, and tri-iodothyronin. No effect on serum 1,25-dihydroxyvitamin D3 or parathyroid hormone could be demonstrated. Adverse effects were mainly related to fluid retention. They were clearly dose-dependent and rapidly reversible. In conclusion, short-term GH treatment stimulates bone formation and bone resorption in postmenopausal women with osteopenia. |
Databáze: | OpenAIRE |
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