Diagnostic Value of the13C Methacetin Breath Test in Various Stages of Chronic Liver Disease
| Autor: | Hamizah Razlan, Sanjiv Mahadeva, Mei-Ling Sharon Tai, Nurhayaty Muhamad Marzuki, Azhar-Shah Shamsul, Tze-Zen Ong |
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| Rok vydání: | 2011 |
| Předmět: |
Breath test
medicine.medical_specialty Cirrhosis Article Subject Hepatology medicine.diagnostic_test business.industry Advanced cirrhosis Gastroenterology Area under the curve medicine.disease Chronic liver disease Predictive value digestive system diseases Liver disease Fibrosis Internal medicine medicine lcsh:Diseases of the digestive system. Gastroenterology lcsh:RC799-869 business |
| Zdroj: | Gastroenterology Research and Practice, Vol 2011 (2011) |
| ISSN: | 1687-630X 1687-6121 |
| DOI: | 10.1155/2011/235796 |
| Popis: | The accuracy of the13C-methacetin breath test (13C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the13C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis. Seventy-seven patients (47 men/30 women, mean age50±16years) were recruited. Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation. The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively. Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99). The13C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis. |
| Databáze: | OpenAIRE |
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