Neuronal DAF-16-to-intestinal DAF-16 communication underlies organismal lifespan extension in C. elegans
| Autor: | Saya Kishimoto, Masanori Nono, Ryoji Abe, Emiko Okabe, Yuri Tani, Masaharu Uno, Eisuke Nishida, Takuya Kurihara, Chika Takahashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cell biology media_common.quotation_subject medicine.medical_treatment Science 02 engineering and technology Biology Article 03 medical and health sciences Daf-16 medicine Genetics Gene Biological sciences Transcription factor Caenorhabditis elegans media_common Gene knockdown Multidisciplinary Insulin fungi Longevity 021001 nanoscience & nanotechnology biology.organism_classification 030104 developmental biology 0210 nano-technology |
| Zdroj: | iScience iScience, Vol 24, Iss 7, Pp 102706-(2021) |
| ISSN: | 2589-0042 |
| Popis: | Summary Previous studies have revealed the importance of inter-tissue communications for lifespan regulation. However, the inter-tissue network responsible for lifespan regulation is not well understood, even in a simple organism Caenorhabditis elegans. To understand the mechanisms underlying systemic lifespan regulation, we focused on lifespan regulation by the insulin/insulin-like growth factor-1 signaling (IIS) pathway; IIS reduction activates the DAF-16/FOXO transcription factor, which results in lifespan extension. Our tissue-specific knockdown and knockout analyses demonstrated that IIS reduction in neurons and the intestine markedly extended lifespan. DAF-16 activation in neurons resulted in DAF-16 activation in the intestine and vice versa. Our dual gene manipulation method revealed that intestinal and neuronal DAF-16 mediate longevity induced by daf-2 knockout in neurons and the intestine, respectively. In addition, the systemic regulation of intestinal DAF-16 required the IIS pathway in intestinal and neurons. Collectively, these results highlight the importance of the neuronal DAF-16-to-intestinal DAF-16 communication for organismal lifespan regulation. Graphical abstract Highlights • Neurons and the intestine are important in the regulation of lifespan • Neuronal daf-2 KO activates not only neuronal DAF-16 but also intestinal DAF-16 • Intestinal daf-2 KO activates not only intestinal DAF-16 but also neuronal DAF-16 • DAF-16-to-DAF-16 communication between neurons and the intestine regulates lifespan Biological sciences; Genetics; Cell biology |
| Databáze: | OpenAIRE |
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