Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors

Autor:	Peter ten Holte, Boudewijn Janssens, Sandrine Gaurrand, Janine Arts, Jacky van Gompel, Virginie Sophie Poncelet, Patrick Angibaud, Ann Marien, Hans De Winter, Bruno Roux, An Aerts, Verdonck Marc Gustaaf Celine, Jacky Van Dun, Luc Van Hijfte, Kristof Van Emelen, Isabelle Noëlle Constance Pilatte, Eddy Jean Edgard Freyne, Wim Floren, Michel Janicot, Sven Franciscus Anna Van Brandt, Jean-Michel Argoullon, Laurence Queguiner
Rok vydání:	2005
Předmět:	Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Stereochemistry medicine.drug_class Hydroxamic Acids Inhibitory Concentration 50 chemistry.chemical_compound Drug Discovery medicine Humans Enzyme Inhibitors Cell Proliferation Pharmacology Histone deacetylase 5 Hydroxamic acid Molecular Structure biology HDAC11 Histone deacetylase 2 HDAC10 Organic Chemistry Histone deacetylase inhibitor General Medicine Histone Deacetylase Inhibitors Pyrimidines chemistry Biochemistry Enzyme inhibitor biology.protein Female Histone deacetylase HeLa Cells
Zdroj:	European Journal of Medicinal Chemistry. 40:597-606
ISSN:	0223-5234
Popis:	A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdbd08dce8f647012c95f1517777f59 https://doi.org/10.1016/j.ejmech.2005.01.008 Zobrazit plný text záznamu Full Text from ScienceDirect