Processing of pharmaceutical materials by electrospraying under reduced pressure
| Autor: | Matti Murtomaa, Jarno Salonen, Maija Nyström, Jorma Roine, Niklas Sandler |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
Chromatography Materials science Chloroform Atmospheric pressure Chemistry Pharmaceutical Organic Chemistry Pharmaceutical Science Amorphous solid chemistry.chemical_compound Crystallinity Solubility chemistry Chemical engineering Drug Discovery Particle-size distribution Pressure Particle Desiccation Particle Size Budesonide Porosity Dissolution |
| Zdroj: | Drug Development and Industrial Pharmacy. 41:116-123 |
| ISSN: | 1520-5762 0363-9045 |
| Popis: | Electrospraying was used in drug particle production.The aim of the research was to evaluate the possibilities to produce drug particles with desired pharmaceutical properties by electrospraying. In particular, the effect of drying pressure on particle properties was studied.A poorly water soluble model drug (budesonide) was dissolved in chloroform, and the solution was atomized by electrospraying. Following this, the charged droplets were neutralized and dried in a drying chamber. The pressure in the drying chamber was varied. The dried particles were collected and analyzed.The pressure reduction had a slight impact on particle size distribution. The particles produced in reduced pressure turned out to be notably more porous than the particles produced in atmospheric pressure. The pressure reduction also affects the degree of crystallinity of the product. The dissolution of the particles produced in reduced pressures was faster to a certain extent than that of the particles produced in atmospheric pressure.A setup for electrospraying materials in a reduced pressure was presented. The pressure reduction had a notable impact on particle morphology. The possibilities to tailor the particle properties during electrospraying were studied. |
| Databáze: | OpenAIRE |
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