Perinatal exposure to environmental contaminants detected in Canadian Arctic human populations changes bone geometry and biomechanical properties in rat offspring
| Autor: | Natalia Stern, Juha Tuukkanen, Lubna E. Elabbas, Christina Trossvik, Rachel A. Heimeier, Helen Håkansson, Wayne J. Bowers, Jamie Nakai, Maria Herlin, Agneta Åkesson, Mikko A. J. Finnilä |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Canada Offspring Health Toxicology and Mutagenesis Physiology Food Contamination Rural Health Biology Toxicology Bone and Bones Rats Sprague-Dawley chemistry.chemical_compound Bone Density Pregnancy medicine Animals Humans Lactation Quantitative computed tomography Methylmercury Femoral neck Mechanical Phenomena Fetus Bone Diseases Developmental Bone Development Perinatal Exposure medicine.diagnostic_test Dose-Response Relationship Drug Arctic Regions Anatomy Environmental Exposure Rats medicine.anatomical_structure chemistry Arctic Maternal Exposure Prenatal Exposure Delayed Effects Gestation Environmental Pollutants Female |
| Zdroj: | Journal of toxicology and environmental health. Part A. 74(19) |
| ISSN: | 1528-7394 |
| Popis: | Arctic inhabitants consume large proportions of fish and marine mammals, and are therefore continuously exposed to levels of environmental toxicants, which may produce adverse health effects. Fetuses and newborns are the most vulnerable groups. The aim of this study was to evaluate changes in bone geometry, mineral density, and biomechanical properties during development following perinatal exposure to a mixture of environmental contaminants corresponding to maternal blood levels in Canadian Arctic human populations. Sprague-Dawley rat dams were dosed with a Northern Contaminant Mixture (NCM) from gestational day 1 to postnatal day (PND) 23. NCM contains 27 contaminants comprising polychlorinated biphenyls, organochlorine pesticides, and methylmercury. Femurs were collected on PND 35, 77 and 350, and diaphysis was analyzed by peripheral quantitative computed tomography and three-point bending test, while femoral neck was assessed in an axial loading experiment. Dose-response modeling was performed to establish the benchmark dose (BMD) for the analyzed bone parameters. Exposure to the high dose of NMC resulted in short and thin femur with reduced mechanical strength in offspring at PND35. BMD of femur length, cortical area, and stiffness were 3.2, 1.6, and 0.8 mg/kg bw/d, respectively. At PND77 femur was still thin, but at PND350 no treatment-related bone differences were detected. This study provides new insights on environmental contaminants present in the maternal blood of Canadian Arctic populations, showing that perinatal exposure induces bone alterations in the young offspring. These findings could be significant from a health risk assessment point of view. |
| Databáze: | OpenAIRE |
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