Rapid Inhibitor Discovery by Exploiting Synthetic Lethality

Autor:	Jacob D. Muscato, Heidi G. Morris, Aaron Mychack, Mithila Rajagopal, Vadim Baidin, Anthony R. Hesser, Wonsik Lee, Kemal İnecik, Laura J. Wilson, Christina M. Kraml, Timothy C. Meredith, Suzanne Walker
Rok vydání:	2022
Předmět:	Methicillin-Resistant Staphylococcus aureus Colloid and Surface Chemistry Bacterial Proteins Microbial Sensitivity Tests General Chemistry Glycolipids Synthetic Lethal Mutations Biochemistry Catalysis Anti-Bacterial Agents
Zdroj:	Journal of the American Chemical Society. 144:3696-3705
ISSN:	1520-5126 0002-7863
DOI:	10.1021/jacs.1c12697
Popis:	Synthetic lethality occurs when inactivation of two genes is lethal but inactivation of either single gene is not. This phenomenon provides an opportunity for efficient compound discovery. Using differential growth screens, one can identify biologically active compounds that selectively inhibit proteins within the synthetic lethal network of any inactivated gene. Here, based purely on synthetic lethalities, we identified two compounds as the only possible inhibitors of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb3bd5b7cccbd32bb847fcd9af6beff https://doi.org/10.1021/jacs.1c12697 Zobrazit plný text záznamu