Analysis of short-term blood pressure variability in pheochromocytoma/paraganglioma patients
| Autor: | Antonio Ciardi, Claudio Letizia, Gino Iannucci, M. Celi, Valeria Bisogni, Giuseppe La Torre, Gaia Oliviero, Giorgio De Toma, Federica Olmati, Gianfranco Tonnarini, Martina Mezzadri, Maria Bonvicini, Vincenza Saracino, Antonio Concistrè, Luigi Petramala |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
medicine.medical_specialty Ambulatory blood pressure hypertension viruses Urinary system Diastole 030209 endocrinology & metabolism 030204 cardiovascular system & hematology lcsh:RC254-282 Article Pheochromocytoma 03 medical and health sciences paraganglioma 0302 clinical medicine Internal medicine medicine Circadian rhythm Risk factor average real variability business.industry weighted standard deviation Metanephrines medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens pheochromocytoma Blood pressure Oncology Cardiology blood pressure variability Average real variability business |
| Zdroj: | Cancers, Vol 11, Iss 5, p 658 (2019) Università degli Studi di Padova-IRIS Cancers Volume 11 Issue 5 |
| Popis: | Data on short-term blood pressure variability (BPV), which is a well-established cardiovascular prognostic tool, in pheochromocytoma and paraganglioma (PPGL) patients is still lack and conflicting. We retrospectively evaluated 23 PPGL patients referred to our unit from 2010 to 2019 to analyze 24 h ambulatory blood pressure monitoring (24-h ABPM)-derived markers of short-term BPV, before and after surgical treatment. PPGL diagnosis was assessed according to guidelines and confirmed by histologic examination. The 24-h ABPM-derived markers of short-term BPV included: circadian pressure rhythm standard deviation (SD) and weighted SD (wSD) of 24-h, daytime, and night-time systolic and diastolic blood pressure (BP) average real variability (ARV) of 24-h, daytime, and night-time systolic and diastolic BP. 7 males and 16 females of 53 ± 18 years old were evaluated. After surgical resection of PPGL we found a significant decrease in 24-h systolic BP ARV (8.8 ± 1.6 vs. 7.6 ± 1.3 mmHg, p < 0.001), in 24-h diastolic BP ARV (7.5 ± 1.6 vs. 6.9 ± 1.4 mmHg, p = 0.031), and in wSD of 24-h diastolic BP (9.7 ± 2.0 vs 8.8 ± 2.1 mmHg, p = 0.050) comparing to baseline measurements. Moreover, baseline 24-h urinary metanephrines significantly correlated with wSD of both 24-h systolic and diastolic BP. Our study highlights as PPGL patients, after proper treatment, show a significant decrease in some short-term BPV markers, which might represent a further cardiovascular risk factor. |
| Databáze: | OpenAIRE |
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