Predominance of the Multiresistant 23F International Clone ofStreptococcus pneumoniaeamong Isolates from Mexico
| Autor: | Fortino Solórzano-Santos, Gabriela Echániz-Aviles, Alexander Tomasz, Maria Elena Velazquez-Meza, María Noemí Carnalla-Barajas, Araceli Soto-Noguerón, José Luis Di Fabio, Yolanda Jiménez-Tapia |
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| Rok vydání: | 1998 |
| Předmět: |
Microbiology (medical)
clone (Java method) Serotype Tetracycline Immunology Erythromycin Microbial Sensitivity Tests Drug resistance Biology medicine.disease_cause Microbiology Streptococcal Infections Streptococcus pneumoniae medicine Pulsed-field gel electrophoresis Humans Serotyping Mexico Pharmacology Drug Resistance Microbial bacterial infections and mycoses Virology Drug Resistance Multiple Electrophoresis Gel Pulsed-Field Penicillin Child Preschool medicine.drug |
| Zdroj: | Microbial Drug Resistance. 4:241-246 |
| ISSN: | 1931-8448 1076-6294 |
| DOI: | 10.1089/mdr.1998.4.241 |
| Popis: | During a surveillance study to determine the relative prevalence of capsular types of Streptococcus pneumoniae and antimicrobial susceptibility of invasive isolates in children5 years old in Mexico City, 220 isolates were collected. The serotype 23F was the most common found, followed by types 6A + B, 14, 19F, and 19A. Diminished susceptibility to penicillin was detected in 106 isolates (48.2%), and high penicillin resistance was found in 49 strains (22.2%), 31 belonging to type 23F. Resistance was also observed to erythromycin (13.1%), to chloramphenicol (43.1%), and to cefotaxime (10.9%). No strains were resistant to ofloxacin or vancomycin. Forty-four of the highly penicillin resistant isolates (penicillin MICor =2.0 microg/ml) were examined with molecular fingerprinting techniques; 29 (65.9%) of these isolates (all except two strains) were serotype 23F and shared subtype variants of PFGE type A characteristic of the internationally spread Spanish/USA clone of S. pneumoniae. These strains were also resistant to trimethoprim/sulfametoxasole (TMP/SMX), chloramphenicol, and tetracycline, and most of them were susceptible to erythromycin. Another 6 of the highly penicillin-resistant strains (serogroups 9 and 14) showed PFGE fingerprints and antimicrobial susceptibility pattern characteristic of a second internationally spread clone (French/Spanish clone) and carried resistance to penicillin and TMP/SMX. The rest of the 9 penicillin-resistant isolates were represented by 7 distinct additional PFGE types. The findings suggest that almost 80% of all highly penicillin resistant strains may have been "imported" into Mexico. |
| Databáze: | OpenAIRE |
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