Intimal Thickening and Disruption of The Media Occur in The Arterial Walls of Coronary Arteries Not Associated With Coronary Arterial Aneurysms in Patients With Kawasaki Disease
| Autor: | Takashi Takeuchi, Shoichi Shibuta, Tomohiro Suenaga, Yasushi Ino, Takashi Kubo, Takashi Akasaka, Nobuyuki Kakimoto, Hiroyuki Suzuki, Tomoya Tsuchihashi, Takayuki Suzuki |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Mucocutaneous Lymph Node Syndrome 030204 cardiovascular system & hematology Coronary Angiography 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Neointima Internal medicine mental disorders medicine Humans Diseases of the circulatory (Cardiovascular) system 030212 general & internal medicine Thrombus Child Retrospective Studies Angiology Coronary artery aneurysm business.industry Research Coronary Aneurysm Infant medicine.disease Coronary Vessels Cardiac surgery Coronary arteries medicine.anatomical_structure Child Preschool RC666-701 Cardiology Female Kawasaki disease Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine Complication business Tomography Optical Coherence Calcification |
| Zdroj: | BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-8 (2021) BMC Cardiovascular Disorders |
| DOI: | 10.21203/rs.3.rs-145808/v1 |
| Popis: | Background Coronary artery aneurysm (CAA) is an important complication of Kawasaki disease (KD) that is associated with arterial structure damage. However, few studies have examined structural changes in coronary arteries that are not associated with CAA. Methods We examined coronary arteries in KD patients with CAAs who underwent follow-up coronary angiography (CAG) and optical coherence tomography (OCT). Coronary arterial branches with no abnormal findings during the most recent CAG were classified into two groups. Arteries with an acute-phase CAA that later regressed were classified as group R; arteries with no abnormal findings on either acute or convalescent phase CAG were classified as group N. Coronary arterial wall structural changes were compared between groups using OCT. Results Fifty-seven coronary arterial branches in 23 patients were evaluated by OCT. Thirty-six branches showed no abnormality during the most recent CAG. Both groups R and N comprised 18 branches. Maximum intimal thicknesses in groups R and N were 475 and 355 µm, respectively (p = 0.007). The incidences of media disruption were 100% and 67%, respectively (p = 0.02). Calcification, macrophage accumulation, and thrombus were not found in either group. Conclusions Intimal thickening and disruption of the media occur in coronary arteries with acute phase CAAs that later regress in the convalescent phase, as well as in arteries with normal CAG findings in the acute and convalescent phases. |
| Databáze: | OpenAIRE |
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