Polydipsia in chronic psychiatric patients: therapeutic trials of clonidine and enalapril
| Autor: | M.D Hedy E. Tasbas, M.D Robert M. Greendyke, Kathleen S. Lewandowski, Alan J. Bernhardt |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Drinking Behavior Angiotensin-Converting Enzyme Inhibitors Clonidine law.invention Randomized controlled trial Double-Blind Method Enalapril law Medicine Psychogenic disease Humans Aged Pharmacology Cross-Over Studies business.industry Middle Aged medicine.disease Crossover study Psychiatry and Mental health Schizophrenia Anesthesia Chronic Disease Delirium Drug Therapy Combination Female Schizophrenic Psychology medicine.symptom business Polydipsia medicine.drug Antipsychotic Agents |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 18(4) |
| ISSN: | 0893-133X |
| Popis: | A six month long double-blind, placebo-controlled, crossover design pharmacological study was conducted on 14 chronically psychotic, institutionalized patients who suffered from chronic water abuse (“psychogenic polydipsia”). Effects of clonidine and enalapril administered separately and individually were assessed for possible beneficial effects on both physiological parameters such as diurnal weight gain, urine output, and serum sodium levels and on signs of delirium as measured by neurobehavioral testing. Improvement, particularly in tests reflecting fluid consumption, was found with either or both drugs in approximately 60% of test subjects, although no behavioral improvement was demonstrated. As a result of evidence for delayed and carry-over effects the authors recommend that future studies employ phases longer than one month and/or include washout periods. |
| Databáze: | OpenAIRE |
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