Epstein‐Barr Virus‐associated Gastric Carcinoma in Japanese Brazilians and Non‐Japanese Brazilians in São Paulo
Autor: | Suminori Akiba, Shoichiro Tsugane, Gerson Shigeaki Hamada, Kiyoshi Iriya, Yoshito Eizuru, Chihaya Koriyama, Tetsuhiko Itoh, Shaw Watanabe, Thiana Yamaguti, Masayoshi Tokunaga, Takashi Aikou |
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Jazyk: | angličtina |
Rok vydání: | 2001 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Epstein-Barr Virus Infections Herpesvirus 4 Human Urban Population Black People Barr virus Gastric carcinoma Comorbidity Japanese immigrants Adenocarcinoma Gastroenterology Article White People Epstein-Barr virus associated gastric carcinoma Japan Stomach Neoplasms Internal medicine hemic and lymphatic diseases Prevalence Medicine Humans Sex Distribution Life Style In Situ Hybridization Aged Retrospective Studies business.industry Middle Aged Oncology Japanese brazilians RNA Viral Female business Epstein Brazil Male predominance |
Zdroj: | Japanese Journal of Cancer Research : Gann |
ISSN: | 1876-4673 0910-5050 |
Popis: | The proportion of Epstein-Barr virus-associated gastric carcinoma (EBV-GC) was examined in 149 Japanese-Brazilian and 151 non-Japanese-Brazilian gastric-carcinoma cases using in situ hybridization (ISH) assay to detect EBV-encoded small RNA (EBER), and the results were compared with our referent Japanese data. We found that 4.7% of cases in Japanese Brazilians were EBER-positive. This frequency was slightly lower than that of the referent Japanese, among whom 6.2% of 2038 gastric-carcinoma cases were EBER-positive. On the other hand, the non-Japanese-Brazilian series showed a significantly higher proportion of EBV-GC (11.2%) than the referent group did (P = 0.01). Although EBV-GC was predominant in males among non-Japanese Brazilians (M / F = 3.6, P = 0.047), as was the case in Japanese (M / F = 2.7), Japanese Brazilians did not show such a male predominance. The sex-ratio difference between the Japanese Brazilians and Japanese was statistically significant (P = 0.005). In conclusion, the present study in Japanese Brazilians and Japanese yielded no evidence suggesting any change in the frequency of EBV-GC caused by migration, except the absence of male predominance, which was observed both in Japanese and non-Japanese Brazilians. |
Databáze: | OpenAIRE |
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