Lymphangiogenesis in Classical Hodgkin Lymphoma - Preliminary Study with Clinicopathological Correlations
| Autor: | Irena Lazarev, Daniel Benharroch, Isebrand Prinsloo, Jacob Gopas |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Metastatic breast
Pathology medicine.medical_specialty Angiogenesis complexity factor 03 medical and health sciences 0302 clinical medicine immune system diseases Prostate hemic and lymphatic diseases Classical Hodgkin lymphoma Medicine 030212 general & internal medicine IκB α Microvessel business.industry Lymphangiogenesis classical Hodgkin lymphoma pRb Lymphatic system medicine.anatomical_structure Oncology Podoplanin Lymphatic vessels BAX 030220 oncology & carcinogenesis business Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | A role for lymphangiogenesis in metastatic breast and prostate cancers has been suggested recently. The relevance of lymphangiogenesis in cancer as a rule, and more specifically in classical Hodgkin lymphoma, is poorly understood in comparison with that of angiogenesis. In a preliminary (pilot) study we have investigated the role of lymphatic vessels growth in 19 cases of classical Hodgkin lymphoma stained with the D2-40 (podoplanin) antibody. In each case, three lymphatic vessels hot spots were scrutinized twice. Of the 57 hot spots thus identified, we chose 15 at random for photography, microvessel counting and image analysis. We determined the mean perimeter, surface area, major axis length and complexity factor for each hot spot and correlated them with clinical and biological features of classical Hodgkin lymphoma. No correlations were found with clinical features. No associations were noted with the standard immuno-markers of classical Hodgkin lymphoma. However, significant inverse correlations were shown with pRb, BAX and IκB-α expression. The mean lymphatic major axis length was inversely correlated with the complexity factor. Last, we carried out an additional clinicopathological correlation of the expression of pRb, BAX and IκB-α in a cohort of classical Hodgkin lymphoma patients previously published. |
| Databáze: | OpenAIRE |
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