Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats
| Autor: | David A. Hart, Hans J. Vogel, Stefan J. Urbanski, Kelsey H. Collins, Heather A. Paul, Raylene A. Reimer, Alissa C. Nicolucci |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Sucrose Magnetic Resonance Spectroscopy Offspring medicine.medical_treatment Oligosaccharides Gut flora Diet High-Fat Real-Time Polymerase Chain Reaction Weight Gain Biochemistry Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Nonalcoholic fatty liver disease Genetics medicine Animals Metabolomics Molecular Biology Triglycerides 2. Zero hunger biology Prebiotic Fatty liver Glucose Tolerance Test medicine.disease biology.organism_classification Obesity 3. Good health Gastrointestinal Microbiome Rats Fatty Liver 030104 developmental biology Endocrinology Prebiotics Female Steatosis Insulin Resistance 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(4) |
| ISSN: | 1530-6860 |
| Popis: | A maternal high-fat/sucrose diet, in the presence of maternal obesity, can program increased susceptibility to obesity and metabolic disease in offspring. In particular, nonalcoholic fatty liver disease risk is associated with poor maternal nutrition and obesity status, which may manifest via alterations in gut microbiota. Here, we report that in a preclinical model of diet-induced maternal obesity, maternal supplementation of a high-fat/sucrose diet with the prebiotic oligofructose improves glucose tolerance, insulin sensitivity, and hepatic steatosis in offspring following a long-term high-fat/sucrose dietary challenge compared with offspring of untreated dams. These improvements are associated with alterations in gut microbial composition and serum inflammatory profiles in early life and improvements in inflammatory and fatty-acid gene expression profiles in tissues. Serum metabolomics analysis highlights potential metabolic links between the gut microbiota and the degree of steatosis, including alterations in 1-carbon metabolism. Overall, our data suggest that maternal prebiotic intake protects offspring against hepatic steatosis and insulin resistance following 21 wk of high fat/sucrose diet, which is in part due to alterations in gut microbiota.-Paul, H. A., Collins, K. H., Nicolucci, A. C., Urbanski, S. J., Hart, D. A., Vogel, H. J., Reimer, R. A. Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats. |
| Databáze: | OpenAIRE |
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