Exposure to radiotherapy for first primary cancer as a risk factor for second primary thyroid cancer: A case-control study
| Autor: | Hector Posso Valencia, Luis Felipe Fierro-Maya, Diana Isabel Cuellar Rivera, Andrés Arturo Cuellar Cuellar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism medicine.disease_cause 03 medical and health sciences Sex Factors 0302 clinical medicine Endocrinology Risk Factors Neoplasms Internal medicine Humans Medicine Thyroid Neoplasms Risk factor Thyroid cancer Thyroid neoplasm Neoplasm Staging Retrospective Studies Radiotherapy business.industry Thyroid Cancer Neoplasms Second Primary General Medicine Odds ratio Middle Aged Thorax medicine.disease Primary tumor Survival Rate Radiation therapy medicine.anatomical_structure Case-Control Studies 030220 oncology & carcinogenesis Female business |
| Zdroj: | Annales d'Endocrinologie. 81:539-544 |
| ISSN: | 0003-4266 |
| DOI: | 10.1016/j.ando.2020.11.005 |
| Popis: | Background Second primary neoplasms are associated with high mortality and morbidity rates in cancer survivors successfully treated for the first malignancy. Studies suggested an association between the type of first neoplasm and risk of subsequent thyroid cancer, with part of this risk attributable to exposure to radiotherapy during treatment of the first primary tumor. This study aimed to determine whether radiotherapy is a risk factor for thyroid cancer in patients previously treated for another neoplasm. Methods This retrospective case-control study included patients diagnosed with their first cancer between 2007 and 2017. Patients who subsequently developed thyroid cancer as a second primary neoplasm were defined as “cases”, and patients who did not develop a second cancer were defined as “controls”. Exposure to radiotherapy was the primary risk factor of interest; other risk factors were the site to which radiotherapy was delivered and the first neoplasm type. Results Exposure to radiotherapy was associated with an increased risk of thyroid cancer (odds ratio [OR] = 2.410, 95% confidence interval [CI]: 1.219–4.764), in particular, in women (OR = 3.121, 95% CI: 1.232–7.907) and in patients receiving radiotherapy to the thorax (OR = 6.298, 95% CI: 2.581–15.370). The median survival time from first cancer recovery to thyroid cancer occurrence was 63.80 months; there was no difference in survival between patients who did and did not receive radiotherapy (P = 0.899). Conclusion Radiation to the thorax can increase the risk of thyroid cancer as a second neoplasm among patients with cancer successfully treated for their first cancer. |
| Databáze: | OpenAIRE |
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