Serotypes, surface proteins, and clinical syndromes of invasive Group B streptococcal infections in northern Taiwan, 1998-2009
| Autor: | Li-Chun Chen, Swee Siang Wong, Li-Chen Lin, Qin-Dong Liu, Chim Ren Tsai, Kochung Tsui, Cheng-Hua Huang |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Serotype
Male Serotypes Bacteremia Tertiary Care Centers Pregnancy Immunology and Allergy Aged 80 and over education.field_of_study Incidence (epidemiology) Incidence Vaccination General Medicine Middle Aged Infectious Diseases Female Microbiology (medical) Adult medicine.medical_specialty Invasive Group B streptococcal infection Adolescent Genotype Population Taiwan Serogroup Streptococcus agalactiae Young Adult Internal medicine Immunology and Microbiology(all) Streptococcal Infections medicine Humans education Hospitals Teaching Disease burden Aged Retrospective Studies General Immunology and Microbiology Molecular epidemiology business.industry Infant Newborn Infant Membrane Proteins Retrospective cohort study medicine.disease Surgery business Multiplex Polymerase Chain Reaction |
| Zdroj: | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 44(1) |
| ISSN: | 1995-9133 |
| Popis: | BackgroundThe incidence of invasive Group B streptococcal (GBS) infections is increasing in the elderly and immunocompromised adults in many countries worldwide. There are, however, few reports regarding the current status of the infection in northern Taiwan. This study investigated retrospectively the molecular epidemiology and clinical syndromes of the invasive GBS diseases in a tertiary care hospital in northern Taiwan over the past decade.MethodsOne hundred twenty episodes of invasive GBS disease were recorded at Cathay General Hospital, a tertiary care, teaching hospital in northern Taiwan, from January 1998 to June 2009. Clinical information was acquired from medical records. Capsular serotypes and alpha family of surface proteins were genotyped with multiplex and specific polymerase chain reaction.ResultsOf all episodes, 58.3% was found in the elderly (age≥65), 36.1% in nonpregnant women and young adults (age 18–64), and 5.9% in the neonates (0–90 days). Case-fatality rate was 6.7%. Eighty-three (69%) of the invasive isolates were available for genotyping. In sharp contrast to the studies in southern Taiwan (1991–2004), Type Ib (26.5%) was the most frequent invasive isolate, followed by V (22.9%), III (18.1%), VI (12%), Ia (10.8%), II (6%), VIII (2.4%), and nontypable strain (1.2%). In particular, Serotype VI, which had been rarely implicated in invasive infection, emerged as a significant pathogen. A significant trend of increase in incidence was observed for the infection (p |
| Databáze: | OpenAIRE |
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