Is there such a thing as protocol immunosuppression in liver transplantation?
| Autor: | Kenny Ching Pan Sze, Simone I. Strasser, Geoffrey W. McCaughan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Graft Rejection
Time Factors medicine.medical_treatment Liver transplantation Bioinformatics Malignancy Risk Assessment Drug Administration Schedule Liver disease Clinical Protocols Risk Factors medicine Humans Precision Medicine Hepatology business.industry Patient Selection Graft Survival Gastroenterology Immunosuppression Hepatitis C medicine.disease Liver Transplantation Calcineurin Treatment Outcome Hepatocellular carcinoma Immunology Etiology Drug Therapy Combination business Immunosuppressive Agents |
| Zdroj: | Expert Review of Gastroenterology & Hepatology. 9:1-4 |
| ISSN: | 1747-4132 1747-4124 |
| DOI: | 10.1586/17474124.2014.954550 |
| Popis: | Protocol immunosuppression in liver transplantation is largely an outdated concept. Immunosuppression is now personalized to the individual patient on the basis of several factors including underlying etiology of original liver disease (e.g., HCV, hepatocellular carcinoma), renal function, metabolic co-morbidities and the patient's immunological state. These include omission of corticosteroids in HCV infection and those with major metabolic risk factors, the minimization of calcineurin inhibitors in the presence of renal dysfunction and the use of mTOR inhibitors in patients with malignancy. The basis for such decision-making is discussed in this editorial. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|