Production of a novel poly(ɛ‐caprolactone)‐methylcellulose electrospun wound dressing by incorporating bioactive glass and Manuka honey
| Autor: | Liliana Liverani, Swathi Naidu Vakamulla Raghu, Aldo R. Boccaccini, Zuzana Neščáková, Katharina Schuhladen |
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| Rok vydání: | 2020 |
| Předmět: |
Keratinocytes
Materials science Polyesters Simulated body fluid Composite number Biomedical Engineering 02 engineering and technology Methylcellulose 010402 general chemistry 01 natural sciences Manuka Honey Cell Line law.invention Biomaterials law Materials Testing Ultimate tensile strength Humans Fiber integumentary system food and beverages Honey 021001 nanoscience & nanotechnology Bandages Electrospinning Anti-Bacterial Agents 0104 chemical sciences Chemical engineering Bioactive glass Wound dressing Glass 0210 nano-technology ddc:600 |
| Zdroj: | Journal of Biomedical Materials Research Part B: Applied Biomaterials. 109:180-192 |
| ISSN: | 1552-4981 1552-4973 |
| Popis: | Wound dressings produced by electrospinning exhibit a fibrous structure close to the one of the extracellular matrix of the skin. In this article, electrospinning was used to fabricate fiber mats based on the well-known biopolymers poly(ɛ-caprolactone) (PCL) and methylcellulose (MC) using benign solvents. The blend fiber mats were cross-linked using Manuka honey and additionally used as a biodegradable platform to deliver bioactive glass particles. It was hypothesized that a dual therapeutic effect can be achieved by combining Manuka honey and bioactive glass. Morphological and chemical examinations confirmed the successful production of submicrometric PCL-MC fiber mats containing Manuka honey and bioactive glass particles. The multifunctional fiber mats exhibited improved wettability and suitable mechanical properties (ultimate tensile strength of 3-5 MPa). By performing dissolution tests using simulated body fluid, the improved bioactivity of the fiber mats by the addition of bioactive glass was confirmed. Additionally, cell biology tests using human dermal fibroblasts and human keratinocytes-like HaCaT cells showed the potential of the fabricated composite fiber mats to be used as wound dressing, specially due to the ability to support wound closure influenced by the presence of bioactive glass. Moreover, based on the results of the antibacterial tests, it is apparent that an optimization of the electrospun fiber mats is required to develop suitable wound dressing for the treatment of infected wounds. |
| Databáze: | OpenAIRE |
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