Implementation of a pharmacogenomic program in a Brazilian public institution
| Autor: | Marcela B. Mansur, Guilherme Suarez-Kurtz, Karolyne Wolch, Vera La Motta, Antonio A Gonçalves, Mariana Emerenciano, Andreia Cristina de Melo, Anna Br Elias, Maria T Accioly, Marcos Ferreira, Alexandre M Palladino, Giovana Kovaleski |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
medicine.medical_specialty business.industry Cost-Benefit Analysis Cancer Public institution Antineoplastic Agents medicine.disease Test (assessment) Pharmacogenomic Testing Irinotecan Government Agencies Pharmacogenomics Family medicine Neoplasms Genetics Molecular Medicine Medicine Humans Christian ministry Dosing Medical prescription business Brazil medicine.drug |
| Popis: | This narrative review describes implementation, current status and perspectives of a pharmacogenomic (PGx) program at the Brazilian National Cancer Institute (INCA), targeting the cancer chemotherapeutic drugs – fluoropyrimidines, irinotecan and thiopurines. This initiative, designed as a research project, was supported by a grant from the Brazilian Ministry of Health. A dedicated task force developed standard operational procedures from recruitment of patients to creating PGx reports with dosing recommendations, which were successfully applied to test 100 gastrointestinal cancer INCA outpatients and 162 acute lymphoblastic leukemia pediatric patients from INCA and seven other hospitals. The program has been subsequently expanded to include gastrointestinal cancer patients from three additional cancer treatment centers. We anticipate implementation of routine pre-emptive PGx testing at INCA but acknowledge challenges associated with this transition, such as continuous financing support, availability of trained personnel, adoption of the PGx-informed prescription by the clinical staff and, ultimately, evidence of cost–effectiveness. |
| Databáze: | OpenAIRE |
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