Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis
| Autor: | Patricia Schneider, Gary Peltz, M C Shanafelt, Hans Yssel, J Anzola, C Soderberg |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Cytotoxicity
Immunologic T cell Immunology Molecular Sequence Data Oligonucleotides Receptors Antigen T-Cell Gene Expression Human leukocyte antigen Spirochaetaceae Lyme Arthritis Polymerase Chain Reaction Interleukin 21 Bacterial Proteins Borrelia burgdorferi Group HLA Antigens T-Lymphocyte Subsets medicine Immunology and Allergy Cytotoxic T cell Humans Borrelia burgdorferi Cloning Molecular Antigens Bacterial Lyme Disease Lymphokines biology Base Sequence Borrelia Lymphokine T-Lymphocytes Helper-Inducer Articles biology.organism_classification Virology Clone Cells medicine.anatomical_structure T-Lymphocytes Cytotoxic |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 0022-1007 |
| Popis: | 18 cloned T cell lines reactive with Borrelia burgdorferi proteins, all CD3+4+8-TCR-alpha/beta+ and restricted by HLA class II proteins, were isolated from four patients with chronic Lyme arthritis. Analysis of these T cell clones indicated that the T cell response to the Lyme disease spirochete is not oligoclonally restricted; yet all produced the same pattern of lymphokines, resembling that of murine type 1 T helper cells, after antigen-specific or nonspecific stimulation. Therefore, a subset of human CD4+ T cells, with a distinct profile of lymphokine secretion, is selectively activated by the pathogen inciting this chronic inflammatory disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|