Synthesis of Oligo-(alkyne-triplet)peptide Constructs
| Autor: | Ola Blixt, Nicolai Stuhr-Hansen, Christian Risinger, Ebbe Engholm |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Organic Chemistry Alkyne Peptide 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Cycloaddition Glycopeptide 0104 chemical sciences 3. Good health Amino acid chemistry.chemical_compound chemistry Peptide synthesis Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters |
| ISSN: | 1523-7060 |
| DOI: | 10.1021/acs.orglett.7b03231 |
| Popis: | Copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) click synthesis of an Fmoc-(trispropargyl)amino acid building block for solid phase peptide synthesis (SPPS) of oligo-(trialkyne)peptide constructs is reported. These can carry potentially indefinite numbers of inherent alkyne-triplets, which are click derivatized with GlcNAc-azide into the corresponding glycopeptides. |
| Databáze: | OpenAIRE |
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