Immunological function of Langerhans cells in HIV infection
| Autor: | Tatsuyoshi Kawamura, Shinji Shimada, Youichi Ogawa, Takamitsu Matsuzawa, Kohji Moriishi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell Count chemical and pharmacologic phenomena Dermatology CD8-Positive T-Lymphocytes Biology Lymphocyte Activation T-Lymphocytes Regulatory Biochemistry Peripheral blood mononuclear cell Virus Tissue Culture Techniques 03 medical and health sciences Immune system HLA-A2 Antigen Humans Cytotoxic T cell Antigen-presenting cell Molecular Biology Cells Cultured Acquired Immunodeficiency Syndrome Toll-like receptor integumentary system Effector virus diseases hemic and immune systems 030104 developmental biology Epidermal Cells Langerhans Cells Immunology Disease Progression HIV-1 Epidermis CD8 |
| Zdroj: | Journal of Dermatological Science. 87:159-167 |
| ISSN: | 0923-1811 |
| DOI: | 10.1016/j.jdermsci.2017.03.015 |
| Popis: | Background Langerhans cells (LCs) are one of the initial target cells for HIV following sexual exposure and they are productively infected by HIV. HIV-infected LCs migrate to the draining lymph nodes (dLNs) and transmit the virus to CD4+ T cells, leading to the dissemination of HIV. In contrast with the role of LCs in initial HIV acquisition, little is known about the modulation of immune responses by HIV-infected LCs. Objective We aimed to elucidate the induction of HIV-specific CD8+ T cells and regulatory T cells (Tregs), both of which play important roles in regulating the progression of HIV infection. Methods We examined the inducibility of HLA-A*0201 restricted HIV-specific CD8+ T cells and Tregs by HIV-primed LCs or HIV-primed dendritic cells (DCs) as a control. Results The number of HIV-specific CD8+ T cells induced by HIV-primed monocyte-derived LCs (mLCs) was significantly higher than that by HIV-primed monocyte-derived DCs (mDCs). Additionally, HIV-specific CD8+ T cells induced by HIV-primed mLCs produced more IFN-γ than HIV-nonspecific CD8+ T cells. HIV-primed human epidermal LCs also induced IFN-γ-producing HIV-specific CD8+ T cells. As for the induction of Tregs, HIV-primed mLCs and human epidermal LCs significantly impaired the induction of FoxP3hiCD45RA− effector Tregs than HIV-unprimed mLCs and human epidermal LCs. Conclusions HIV-primed LCs trigger beneficial immune responses against HIV infection through the increased induction of HIV-specific CD8+ T cells and the decreased induction of effector Tregs in the initial phase of HIV infection, thereby contributing to the prolonged onset of AIDS. |
| Databáze: | OpenAIRE |
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