Reproduction studies on sodium meclofenamate in comparison to aspirin and phenylbutazone
| Autor: | D.H. Kaump, James L. Schardein, A.T. Blatz, E. T. Woosley |
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| Rok vydání: | 1969 |
| Předmět: |
Male
medicine.medical_specialty Offspring media_common.quotation_subject Anti-Inflammatory Agents Biology Toxicology Reproductive cycle Fetus Pregnancy Internal medicine medicine Phenylbutazone Animals ortho-Aminobenzoates media_common Pharmacology Aspirin Analgesics Reproduction Abnormalities Drug-Induced Rats Endocrinology Fertility Animals Newborn Reproductive process Meclofenamate Sodium Female Rabbits medicine.drug |
| Zdroj: | Toxicology and applied pharmacology. 15 |
| ISSN: | 0041-008X |
| Popis: | Three pharmacologically similar anti-inflammatory agents, sodium meclofenamate (CI-583 Na), aspirin, and phenylbutazone were given to rats and rabbits to determine their effect on reproduction. Approximately biologically equivalent doses, multiples of 3–5 times the usually recommended human dose, were given during three periods of the reproductive cycle. Under the conditions of this experiment, aspirin was embryocidal at higher doses, and induced severe alteration in the reproductive process and skeletal malformations of the offspring at lower doses. Phenylbutazone had less effect, but there was reduction in the size of litters produced, a moderately increased fetal mortality, and minor malformations in the offspring. CI-583 Na had the least effect, with a slight increase in fetal mortality. |
| Databáze: | OpenAIRE |
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