Higher Viral Load Drives Infrequent Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Between Asymptomatic Residence Hall Roommates
| Autor: | Cole R Hager, Leslie A. Leinwand, Daniel B. Larremore, Morgan R Fink, Matthew B. McQueen, Christopher D Ozeroff, Gloria R Brisson, Roy Parker, Kristen K. Bjorkman, Tassa K Saldi, Leisha Conners Bauer, Patrick K. Gonzales, Jack C Davis, Jennifer Kovarik, Erika Lasda, Kimngang L Tat |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Isolation (health care) medicine.disease_cause Asymptomatic law.invention Young Adult Major Articles and Brief Reports law Pandemic medicine Humans Immunology and Allergy Young adult Students Asymptomatic Infections Pandemics Coronavirus SARS-CoV-2 business.industry COVID-19 Viral Load Infectious Diseases Transmission (mechanics) Residence medicine.symptom business Viral load |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiab386 |
| Popis: | Background The coronavirus disease 2019 pandemic spread to >200 countries in Methods Given high residence hall student density, the University of Colorado Boulder established a mandatory weekly screening test program. We analyzed longitudinal data from 6408 students and identified 116 likely transmission events in which a second roommate tested positive within 14 days of the index roommate. Results Although the infection rate was lower in single-occupancy rooms (10%) than in multiple-occupancy rooms (19%), interroommate transmission occurred only about 20% of the time. Cases were usually asymptomatic at the time of detection. Notably, individuals who likely transmitted had an average viral load approximately 6.5-fold higher than individuals who did not (mean quantification cycle [Cq], 26.2 vs 28.9). Although students with diagnosed SARS-CoV-2 infection moved to isolation rooms, there was no difference in time to isolation between cases with or without interroommate transmission. Conclusions This analysis argues that interroommate transmission occurs infrequently in residence halls and provides strong correlative evidence that viral load is proportional to transmission probability. |
| Databáze: | OpenAIRE |
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