Modular Fragment Synthesis and Bioinformatic Analysis Propose a Revised Vancoresmycin Stereoconfiguration
| Autor: | Lukas M. Wingen, Martina Adamek, Max Schönenbroicher, Dirk Menche, Sebastian Essig, Maximilian Seul, Michael Kurz, Nadine Ziemert, Stefanie Spindler |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Bioinformatics analysis
Computational biology 010402 general chemistry 01 natural sciences Biochemistry Polyketide chemistry.chemical_compound Fragment (logic) Vancomycin Gene cluster Physical and Theoretical Chemistry Biological Products Natural product Molecular Structure 010405 organic chemistry business.industry Chemistry Organic Chemistry Computational Biology Stereoisomerism Modular design Anti-Bacterial Agents 0104 chemical sciences Multigene Family Polyketides business |
| Zdroj: | Organic Letters. 23:1175-1180 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.0c03957 |
| Popis: | Elaborate fragments of the proposed stereostructure of the complex polyketide antibiotic vancoresmycin have been synthesized in a stereoselective fashion based on a modular and convergent approach. Significant nuclear magnetic resonance differences in one of these subunits compared with the natural product question the proposed stereoconfiguration. Consequently, an extensive bioinformatics analysis of the biosynthetic gene cluster was carried out, leading to a revised stereoconfigurational proposal for this highly potent antibiotic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|