Locally injected autologous platelet-rich plasma enhanced tissue perfusion and improved survival of long subdermal plexus skin flaps in dogs
| Autor: | Panayiotis Loukopoulos, N. Giannakas, Lysimachos G. Papazoglou, Dimitra Psalla, George Kazakos, D. Dionyssiou, Ioannis Savvas, A. Chantes, Maria Karayannopoulou, Maria Kritsepi-Konstantinou |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty 030230 surgery Beagle Surgical Flaps Abdominal wall 03 medical and health sciences Dogs 0302 clinical medicine medicine Animals Autologous platelet Skin Plexus General Veterinary Platelet-Rich Plasma business.industry Laser Doppler velocimetry Surgery medicine.anatomical_structure 030220 oncology & carcinogenesis Platelet-rich plasma Female Animal Science and Zoology Veterinary surgery business Perfusion |
| Zdroj: | Charles Sturt University |
| ISSN: | 2567-6911 0932-0814 |
| DOI: | 10.3415/vcot-14-02-0030 |
| Popis: | Summary Objectives: Distal flap necrosis remains a major complication in subdermal plexus (random) skin flaps. Platelet-rich plasma (PRP) has been shown to improve the survival of ischemic random skin flaps in rats. The objective of this study was to evaluate the effect of locally injected autologous PRP on the survival of long (5:1 length-to-width ratio) subdermal plexus skin flaps in dogs. Methods: A 2x10 cm subdermal plexus skin flap was created bilaterally on the abdominal wall of six Beagle dogs. One randomly selected side received 2.5 ml of fresh autologous PRP injected evenly between sutures underneath the flap, whereas the other side was left untreated (control). Skin flap survival was evaluated macroscopically, histologically and by laser-Doppler flowmetry measurements of tissue perfusion. Results: Flap percentage survival on day 10 (96.3% versus 74.5%; p = 0.046) and tissue perfusion (p Clinical significance: The use of locally injected autologous PRP increases tissue perfusion and improves the survival of long subdermal plexus skin flaps in dogs. |
| Databáze: | OpenAIRE |
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