Craf-1 protein kinase is essential for mouse development
| Autor: | Ulf R. Rapp, Anne M. Zimmer, Andreas Zimmer, Louis F. Stancato, Andrew C. Larner, Leszek Wojnowski, Heidi Hahn, Thomas William Beck |
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| Rok vydání: | 1998 |
| Předmět: |
Embryology
Cell division Molecular Sequence Data Mutant Mice Inbred Strains Biology Mice Species Specificity Cell surface receptor Animals Abnormalities Multiple c-Raf MAPK1 Protein kinase A Fetal Death Regulation of gene expression Base Sequence TNF Receptor-Associated Factor 3 Kinase Gene Expression Regulation Developmental Proteins Fibroblasts Molecular biology Mice Mutant Strains Cell biology Mutation Cell Division Developmental Biology |
| Zdroj: | Mechanisms of Development. 76:141-149 |
| ISSN: | 0925-4773 |
| Popis: | The three mammalian Raf serine/threonine protein kinases mediate the transduction of proliferative and differentiative signals from a variety of cell surface receptors to the nucleus. We report here that Craf-1 is essential for mouse development, as its mutation results in embryonic lethality. Developmental defects are found in mutant placentas as well as in the skin and in the lungs of mutant embryos. Craf-1 mutants also display a generalized growth retardation which is consistent with the ubiquitous expression of Craf-1 and which could be due to the reduced proliferation of mutant cells. Interestingly, the time-point of embryonal death varies depending on the genetic background. This suggests that Craf-1-mediated signaling is affected by genetic background-specific alleles of other genes. |
| Databáze: | OpenAIRE |
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