Amino Alcohols from the Ascidian Pseudodistoma sp
| Autor: | Boon Jo Rho, Minjung You, Jongheon Shin, Tae Hyung Won, Dong-Chan Oh, Ki-Bong Oh, So-Hyoung Lee |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pseudodistoma sp
bioactivities Stereochemistry amino alcohols pseudoaminols stereochemistry Pharmaceutical Science Antineoplastic Agents Alcohol Pseudodistoma Article chemistry.chemical_compound Anti-Infective Agents Republic of Korea Drug Discovery Chemical conversion Animals Humans Organic chemistry Urochordata Cytotoxicity lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) Chemistry Spectrum Analysis Antimicrobial lcsh:Biology (General) Sodium-Potassium-Exchanging ATPase |
| Zdroj: | Marine Drugs MARINE DRUGS(12): 6 Marine Drugs; Volume 12; Issue 6; Pages: 3754-3769 Marine Drugs, Vol 12, Iss 6, Pp 3754-3769 (2014) |
| ISSN: | 1660-3397 |
| Popis: | Seven new amino alcohol compounds, pseudoaminols A–G (1–7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na+/K+-ATPase. |
| Databáze: | OpenAIRE |
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