Role of m6A in Embryonic Stem Cell Differentiation and in Gametogenesis
| Autor: | Jacob H. Hanna, Lior Lasman, Noa Novershtern |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis Cellular differentiation Cell lcsh:Medicine Biology Biochemistry Genetics and Molecular Biology (miscellaneous) Biochemistry 03 medical and health sciences 0302 clinical medicine Cancer stem cell stem cells Genetics medicine lcsh:QH301-705.5 Gametogenesis 030304 developmental biology 0303 health sciences m6a Mechanism (biology) oogenesis MRNA modification lcsh:R n6-methyladenosine Embryonic stem cell rna modification spermatogenesis Cell biology medicine.anatomical_structure lcsh:Biology (General) Stem cell 030217 neurology & neurosurgery |
| Zdroj: | Epigenomes, Vol 4, Iss 1, p 5 (2020) |
| ISSN: | 2075-4655 |
| Popis: | The rising field of RNA modifications is stimulating massive research nowadays. m6A, the most abundant mRNA modification is highly conserved during evolution. Through the last decade, the essential components of this dynamic mRNA modification machinery were found and classified into writer, eraser and reader proteins. m6A modification is now known to take part in diverse biological processes such as embryonic development, cell circadian rhythms and cancer stem cell proliferation. In addition, there is already firm evidence for the importance of m6A modification in stem cell differentiation and gametogenesis, both in males and females. This review attempts to summarize the important results of recent years studying the mechanism underlying stem cell differentiation and gametogenesis processes. |
| Databáze: | OpenAIRE |
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