Molecular Characterization of Imported and Autochthonous Dengue in Northeastern Spain
| Autor: | Ana Meca Martínez, Anna Vilamala, Mireia Navarro, Aida Peiró-Mestres, Ana Vázquez, Mireia Jané, Miguel J. Martínez, Nuria Torner, Ana Calderón, Josefa Perez, María José Portillo Navarro, Alexander Navarro, María Ángeles Pulido, Rosa Rubio, María Paz Sánchez-Seco, Izaskun Alejo-Cancho, Elena Sulleiro, Jose Muñoz, Josep Barrachina, Daniel Camprubí-Ferrer, Verónica Gonzalo, Rosa Albarracin, Jessica Navero-Castillejos, Carmina Martí, Aroa Silgado, Jaume Llaberia, Rosa Benitez, Montserrat Roldán, Virginia Plasencia, Miguel Micó, Teresa Falgueras |
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| Přispěvatelé: | Instituto de Salud Carlos III, Agency for Administration of University and Research, Government of Catalonia (España), Plan Nacional de I+D+i (España), Societat Catalana de Malalties Infeccioses i Microbiologia Clínica, [Navero-Castillejos J] Department of Clinical Microbiology, Hospital Clinic de Barcelona, Barcelona, Spain. Barcelona Institute for Global Health (ISGlobal), Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain. [Benitez R] North Metropolitan International Health Unit PROSICS, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. [Torner N] CIBER Epidemiology and Public Health CIBERESP, University of Barcelona, Barcelona, Spain. [Muñoz J, Camprubí-Ferrer D] Barcelona Institute for Global Health (ISGlobal), Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain. [Peiró-Mestres A] Department of Clinical Microbiology, Hospital Clinic de Barcelona, Barcelona, Spain. [Martí C] Hospital General de Granollers, Granollers, Spain, Hospital General de Granollers |
| Rok vydání: | 2021 |
| Předmět: |
Male
Serotype Microbiologia Communicable diseases autochthonous transmission Dengue virus medicine.disease_cause molecular epidemiology Dengue fever Dengue Aedes Communicable Diseases Imported Genotype Phylogeny Malalties transmissibles - Transmissió Surveillance biology Middle Aged QR1-502 Europe ambiente y salud pública::salud pública::transmisión de una enfermedad infecciosa [ATENCIÓN DE SALUD] Environment and Public Health::Public Health::Disease Transmission Infectious [HEALTH CARE] Infectious Diseases Geography Molecular Diagnostic Techniques Molecular epidemiology surveillance Female Public Health Adult Aedes albopictus Epidemiologia molecular Investigative Techniques::Epidemiologic Methods::Molecular Epidemiology [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Autochthonous transmission Microbiology Arbovirus Article Young Adult Virology medicine Animals Humans Aged Dengue Virus Malalties infeccioses medicine.disease biology.organism_classification Virus Diseases::Arbovirus Infections::Dengue [DISEASES] dengue técnicas de investigación::métodos epidemiológicos::epidemiología molecular [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Spain virosis::infecciones por arbovirus::dengue [ENFERMEDADES] |
| Zdroj: | Repisalud Instituto de Salud Carlos III (ISCIII) Viruses, Vol 13, Iss 1910, p 1910 (2021) Scientia VIRUSES-BASEL r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname Dipòsit Digital de la UB Universidad de Barcelona Viruses Volume 13 Issue 10 |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13101910 |
| Popis: | Dengue is the most significant arbovirus worldwide and a public health threat to non-endemic areas in which Aedes vectors are present. Autochthonous dengue transmission has been reported in several European countries in the last decade. Infected travelers from endemic regions arriving to areas colonized by Aedes albopictus in Europe need to be monitored in surveillance and control programs. We aimed to perform molecular characterization of RT-PCR-positive dengue cases detected in Catalonia, northeastern Spain, from 2013 to 2018. The basic demographic information and the geographical regions of importation were also analyzed. One-hundred four dengue cases were studied (103 imported infections and the first autochthonous case in our region). The dengue virus strains detected were serotyped and genotyped using molecular methods, and phylogenetic analyses were conducted. All four dengue serotypes were detected in travelers, including up to 10 different genotypes, reflecting the global circulation of dengue in endemic areas. The primary travel-related case of the 2018 autochthonous transmission was not identified, but the molecular analysis revealed dengue serotype 1, genotype I of Asian origin. Our results highlight the diversity of imported dengue virus strains and the role of molecular epidemiology in supporting arbovirus surveillance programs. This research was partially supported by Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR)-Departament d’Empresa i Coneixement. Generalitat de Catalunya (grant 2017 SGR 794 to M.J.M.), by Instituto de Salud Carlos III-Red de Enfermedades Tropicales, Subprograma Redes Temáticas de Investigación Cooperativa en Salud Plan Estatal de I + D + I 2013–2016-Federación Española de Enfermedades Raras [Una Manera de Hacer Europa] (project RD16CIII/0003/0003 to M.P.S.S.) and by Societat Catalana de Malalties Infeccioses i Microbiologia Clínica (grant Agustí Pumarola 2020 to J.N.-C.). Sí |
| Databáze: | OpenAIRE |
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